CDH1 and HDAC1

Number of citations: 0 (PubMedID 15388328)
Data Source: HPRD (in vitro)

		CDH1	HDAC1
Name		cadherin 1	histone deacetylase 1
Structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol NuRD Complex Transcription Repressor Complex Protein-containing Complex Neuronal Cell Body Sin3-type Complex
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding P53 Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Enzyme Binding Nucleosomal DNA Binding Protein Lysine Deacetylase Activity Krueppel-associated Box Domain Binding Histone Deacetylase Binding Metal Ion Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Promoter-specific Chromatin Binding
	Biological Process	Cell Morphogenesis Desmosome Assembly Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Neuron Projection Development Cell Junction Assembly Adherens Junction Organization Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of DNA-templated Transcription Regulation Of Transport Cellular Response To Lithium Ion Response To Heparin Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Response To Gram-positive Bacterium Positive Regulation Of Protein Localization	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Endoderm Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Epidermal Cell Differentiation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Hippocampus Development Neuron Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Heterochromatin Formation Circadian Regulation Of Gene Expression Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Fate Specification Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Transcription Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Smooth Muscle Cell Proliferation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Androgen Receptor Signaling Pathway Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 p75NTR negatively regulates cell cycle via SC1 Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Deactivation of the beta-catenin transactivating complex ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Repression of WNT target genes Repression of WNT target genes Regulation of TP53 Activity through Acetylation G1/S-Specific Transcription RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Nuclear events stimulated by ALK signaling in cancer Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		None	Valproic acid Arsenic trioxide Decitabine Zinc Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Fingolimod Mocetinostat Entinostat Abexinostat Abexinostat Givinostat Pyroxamide Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer	None
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725 ) Colorectal cancer ( 19011631 ) Colorectal cancer or advanced adenoma ( 30510241 ) Cutaneous malignant melanoma ( 26237428 32341527 ) Glycated hemoglobin levels ( 34059833 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Late-onset Alzheimer's disease ( 27770636 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 32888494 27863252 ) Nevus count or cutaneous melanoma ( 32341527 ) Red cell distribution width ( 32888494 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Ulcerative colitis ( 19915572 )	No GWAS studies recorded
Interacting Genes		74 interacting genes: ACTR3 AKT1 ANAPC7 AOPEP ARHGAP32 ARVCF AURKB CA9 CASP3 CASP8 CBLL1 CCNB1 CDC42 CDK8 CHEK1 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 DNMT3A EGFR ERBIN EZR FADD FARP2 FER FGFR1 FYN GALNT12 GNA12 GNA13 GSK3B HDAC1 HDAC2 HEMGN HRAS HSD17B3 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MAP2K1 MAPK3 MKI67 MSANTD3 MYO6 NANS NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM PTTG1 RAB8B RRM2 SFRP2 STX17 TMOD1 UCA1 UCHL3 VCL YES1 ZNF510	187 interacting genes: APEX1 AR ARID4A ATF3 ATRX BAZ2A BCL3 BCL6 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CCN5 CDC20 CDH1 CDKN1A CDYL CEBPA CHD1 CHD4 CHFR CIITA CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 ERCC6 EZH2 FKBP3 FOXG1 FRA10F GCM1 GPS2 H2AC1 H3-4 H3C1 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HMGB1 HNRNPD HR HUS1 IKZF1 ING1 IRF5 JDP2 JUP KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR MAD1L1 MAGEA1 MBD2 MBD3 MBD4 MDM2 MECOM MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NR3C1 NRIP1 NUP98 PARP1 PCNA PEX14 PHB1 PHB2 PHF12 PHF21A PIAS3 PIAS4 PITX2 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA PTOV1 RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RUNX1T1 RUNX3 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SERPINB5 SETDB1 SIN3A SIN3B SMAD2 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUMO2 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBC UBE2I USP38 USP43 VHL ZBTB16 ZMYND11 ZNF76
Entrez ID		999	3065
HPRD ID		01885	03143
Ensembl ID		ENSG00000039068	ENSG00000116478
Uniprot IDs		A0A0U2ZQU7 B3GN61 P12830 Q9UII7	Q13547 Q6IT96
PDB IDs		1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG 6VEL 7STZ 8H62	4BKX 5ICN 6Z2J 6Z2K 7AO8 7AO9 7AOA 7SME 8VOJ 8VPQ 8VRT
GO Terms Enriched among Interactors		Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cell Motility Regulation Of Cell Migration Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Cytoplasm Focal Adhesion Cadherin Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Anchoring Junction Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Cell Cortex Negative Regulation Of Apoptotic Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Protein Catabolic Process Regulation Of Cell Adhesion Regulation Of Protein Metabolic Process Positive Regulation Of Cell Migration Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Cycle Nucleus Positive Regulation Of Cell Motility Negative Regulation Of Cell Motility Cytosol Cytoskeleton Positive Regulation Of Locomotion ERBB Signaling Pathway Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Organization	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process DNA Binding Transcription Corepressor Activity Histone Deacetylase Binding Chromatin Chromatin Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Epigenetic Regulation Of Gene Expression DNA-binding Transcription Factor Binding Transcription Regulator Complex Regulation Of Developmental Process Regulation Of Cell Differentiation Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Sin3-type Complex Sequence-specific DNA Binding