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CDH1 and EZR
Number of citations of the paper that reports this interaction (PubMedID
25468996
)
54
Data Source:
BioGRID
(proximity labelling technology, affinity chromatography technology)
HPRD
(in vivo)
CDH1
EZR
Description
cadherin 1
ezrin
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Endosome
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Adherens Junction
Cytoplasmic Side Of Plasma Membrane
Actin Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Flotillin Complex
Lamellipodium
Cell Junction
Desmosome
Cortical Actin Cytoskeleton
Apical Junction Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Anchoring Junction
Postsynapse
Glutamatergic Synapse
Fibrillar Center
Ruffle
Immunological Synapse
Uropod
Extracellular Space
Cytoplasm
Endosome
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Microvillus
Brush Border
Adherens Junction
Focal Adhesion
Cell Cortex
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Filopodium
Cortical Cytoskeleton
Microvillus Membrane
Vesicle
Ruffle Membrane
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Plasma Membrane Raft
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cell Periphery
Molecular Function
Calcium Ion Binding
Protein Binding
Beta-catenin Binding
Ankyrin Binding
GTPase Activating Protein Binding
Identical Protein Binding
Gamma-catenin Binding
Cadherin Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Cell-cell Adhesion Mediator Activity
Protein Tyrosine Kinase Binding
RNA Binding
Actin Binding
Protein Binding
Microtubule Binding
Cytoskeletal Protein Binding
Protein Domain Specific Binding
Protein Kinase A Catalytic Subunit Binding
Protein Kinase A Regulatory Subunit Binding
Identical Protein Binding
S100 Protein Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Protein Kinase A Binding
ATPase Binding
Disordered Domain Specific Binding
Biological Process
Cell Morphogenesis
Desmosome Assembly
Cell-cell Junction Assembly
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Synapse Assembly
Response To Xenobiotic Stimulus
Response To Toxic Substance
Regulation Of Gene Expression
Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Cell Migration
Pituitary Gland Development
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Neuron Projection Development
Cell Junction Assembly
Adherens Junction Organization
Positive Regulation Of Protein Import Into Nucleus
Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of DNA-templated Transcription
Regulation Of Transport
Cellular Response To Lithium Ion
Response To Heparin
Cellular Response To Indole-3-methanol
Protein Localization To Plasma Membrane
Cell-cell Adhesion
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Response To Gram-positive Bacterium
Positive Regulation Of Protein Localization
Negative Regulation Of Transcription By RNA Polymerase II
Intestinal D-glucose Absorption
Sphingosine-1-phosphate Receptor Signaling Pathway
Leukocyte Cell-cell Adhesion
Regulation Of Cell Shape
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Gland Morphogenesis
Membrane To Membrane Docking
Microvillus Assembly
Actin Cytoskeleton Organization
Astral Microtubule Organization
Protein-containing Complex Localization
Receptor Internalization
Regulation Of Microvillus Length
Negative Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Establishment Or Maintenance Of Apical/basal Cell Polarity
Positive Regulation Of Multicellular Organism Growth
Cortical Microtubule Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Protein Catabolic Process
Filopodium Assembly
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Establishment Of Centrosome Localization
Establishment Of Endothelial Barrier
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Protein Localization To Cell Cortex
Postsynaptic Actin Cytoskeleton Organization
Regulation Of Non-canonical NF-kappaB Signal Transduction
Regulation Of Organelle Assembly
Terminal Web Assembly
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Apoptotic cleavage of cell adhesion proteins
Adherens junctions interactions
RHO GTPases activate IQGAPs
InlA-mediated entry of Listeria monocytogenes into host cells
Regulation of CDH1 Function
Regulation of CDH1 mRNA translation by microRNAs
Degradation of CDH1
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Formation of definitive endoderm
Transcriptional and post-translational regulation of MITF-M expression and activity
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Developmental Lineage of Mammary Stem Cells
Netrin-1 signaling
Recycling pathway of L1
Recycling pathway of L1
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
Penile cancer
Breast cancer
Gastric cancer
Nasopharyngeal cancer
Hepatocellular carcinoma
Thyroid cancer
GWAS
Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease (
34020725
)
Colorectal cancer (
19011631
)
Colorectal cancer or advanced adenoma (
30510241
)
Cutaneous malignant melanoma (
26237428
32341527
)
Glycated hemoglobin levels (
34059833
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
32888494
)
Late-onset Alzheimer's disease (
27770636
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Nevus count or cutaneous melanoma (
32341527
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Ulcerative colitis (
19915572
)
Bladder cancer (smoking interaction) (
24662972
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Hair color (
29662168
)
Refractive error (
32231278
)
Interacting Genes
74 interacting genes:
ACTR3
AKT1
ANAPC7
AOPEP
ARHGAP32
ARVCF
AURKB
CA9
CASP3
CASP8
CBLL1
CCNB1
CDC42
CDK8
CHEK1
CSE1L
CSNK2A1
CTNNA1
CTNNB1
CTNND1
CTNND2
DNMT3A
EGFR
ERBIN
EZR
FADD
FARP2
FER
FGFR1
FYN
GALNT12
GNA12
GNA13
GSK3B
HDAC1
HDAC2
HEMGN
HRAS
HSD17B3
IQGAP1
IRS1
ITGAE
ITGB7
JUP
KEAP1
MAD2L2
MAP2K1
MAPK3
MKI67
MSANTD3
MYO6
NANS
NDRG1
NEDD9
NFE2L2
PIP5K1C
PKD1
PKP4
PPP1CA
PSEN1
PTPN14
PTPRF
PTPRM
PTTG1
RAB8B
RRM2
SFRP2
STX17
TMOD1
UCA1
UCHL3
VCL
YES1
ZNF510
57 interacting genes:
ACTB
ACTC1
ADORA2B
ADRA1B
ARF6
ARHGDIB
CD44
CDH1
CDK5
CEBPA
CFTR
CLIC5
CTNNB1
DLG1
EGFR
ERBB3
FAS
FASLG
GZMM
ICAM1
ICAM2
ICAM3
IQGAP1
L1CAM
LCK
MDM2
MME
MPP3
MSN
NF2
NHERF1
NHERF2
PALLD
PIK3R1
PRKAR2A
PRKCA
PTK2
PTPRC
RDX
ROCK1
RSPH1
S100P
SCYL3
SDC2
SELL
SELP
SLC26A4-AS1
SPN
SUMO2
TBC1D10A
TMEM8B
TSC1
USP1
VCAM1
VPS11
WFDC1
WWOX
Entrez ID
999
7430
HPRD ID
01885
00475
Ensembl ID
ENSG00000039068
ENSG00000092820
Uniprot IDs
A0A0U2ZQU7
B3GN61
P12830
Q9UII7
P15311
PDB IDs
1O6S
2O72
2OMT
2OMU
2OMV
2OMX
2OMY
2OMZ
3FF7
3FF8
3L6X
3L6Y
4ZT1
4ZTE
6CXY
6OLE
6OLF
6OLG
6VEL
7STZ
8H62
1NI2
4RM8
4RM9
4RMA
7T1K
7T1L
Enriched GO Terms of Interacting Partners
?
Cell-cell Adhesion
Adherens Junction
Cell Adhesion
Regulation Of Cell Motility
Regulation Of Cell Migration
Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Cytoplasm
Focal Adhesion
Cadherin Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Junction
Regulation Of Signal Transduction
Intracellular Signal Transduction
Signal Transduction
Anchoring Junction
Regulation Of Signaling
Regulation Of Cell Communication
Plasma Membrane
Regulation Of Apoptotic Signaling Pathway
Regulation Of Cell Projection Organization
Regulation Of Mitotic Cell Cycle
Response To Xenobiotic Stimulus
Cell Cortex
Negative Regulation Of Apoptotic Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Protein Catabolic Process
Regulation Of Cell Adhesion
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Migration
Cell Motility
Regulation Of Cell Population Proliferation
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cell Cycle
Nucleus
Positive Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Cytosol
Cytoskeleton
Positive Regulation Of Locomotion
ERBB Signaling Pathway
Cell Migration
Positive Regulation Of Signal Transduction
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Component Organization
Plasma Membrane
Cell Adhesion
Cell-cell Adhesion
Focal Adhesion
Leukocyte Cell-cell Adhesion
Cell Migration
Cell Motility
Microvillus
Regulation Of Intracellular Signal Transduction
Lamellipodium
Extracellular Exosome
Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Cell Adhesion
Membrane To Membrane Docking
Regulation Of MAPK Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Leukocyte Tethering Or Rolling
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Positive Regulation Of Transport
Regulation Of Cell-cell Adhesion
Filopodium
Regulation Of Developmental Process
Regulation Of Cell Migration
Cell Projection
Regulation Of Signal Transduction
Leukocyte Adhesion To Vascular Endothelial Cell
Regulation Of Cellular Localization
Regulation Of Apoptotic Process
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Membrane Docking
Cell Surface
Cellular Developmental Process
Regulation Of Vesicle-mediated Transport
Regulation Of Cell Motility
Regulation Of Programmed Cell Death
Apical Plasma Membrane
Integrin Binding
Developmental Process
Regulation Of Locomotion
Cell-substrate Adhesion
T Cell Activation
Cell-matrix Adhesion
Ruffle
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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