TRIM3 and TRIM21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM3	TRIM21
Description		tripartite motif containing 3	tripartite motif containing 21
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Dendrite Cell Projection	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Stress Granule SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Toll-like Receptor Signaling Pathway Nervous System Development Protein Transport Protein Ubiquitination Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination	Autophagosome Assembly Protein Polyubiquitination Protein Monoubiquitination Canonical NF-kappaB Signal Transduction Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Stress Granule Assembly Response To Type II Interferon Stress Granule Disassembly Protein K27-linked Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Protein Autoubiquitination Cellular Response To Chemical Stress Pyroptotic Inflammatory Response Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Interferon gamma signaling	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Malaria ( 31844061)	Lung cancer ( 28604730) Malaria ( 31844061)
Interacting Genes		34 interacting genes: ACTN4 ASL CDKN1A CEP70 CSNK1D CSNK1E DNMT1 FXR1 FXR2 KCTD7 KIF21B LNX1 LRRC8E MYO5A MYO5B ROPN1 TEAD1 TEAD2 TNFAIP3 TPTEP2-CSNK1E TRIM21 TSC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2G2 UBE2K UBE2U UBE2W UBE2Z USP32	86 interacting genes: AGO4 AIFM2 ALOX15B APC ATG5 CASP8AP2 CBX4 CDC34 CDKN1A CLSPN CUL1 CWC25 DAXX DCP2 DLGAP1-AS2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 G3BP1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 LPP MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NAT8 NIF3L1 PFKP PPP1CA RAB11FIP1 RAB11FIP5 RNF111 RO60 SAMHD1 SETD7 SIRT5 SKP2 STK3 TBK1 TCP11L1 TNS4 TP53 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2I UBE2L3 UBE2N UBE2V1 UBE2W USP15 USP2 USP4 VPS9D1 WEE2-AS1 XAF1 YJU2 YWHAZ ZBTB16
Entrez ID		10612	6737
HPRD ID		05690	00170
Ensembl ID		ENSG00000110171	ENSG00000132109
Uniprot IDs		B7Z5Y8 O75382	P19474
PDB IDs		7O0B 7QRW 8AMR	2IWG 5JPX 5OLM 6FGA 6S53 7BBD 8A58 8Y58 8Y59 8Y5B 9QBA
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process ATP Binding Proteolysis Involved In Protein Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Nucleotide Binding Protein Monoubiquitination Macromolecule Catabolic Process Protein K11-linked Ubiquitination Protein Metabolic Process TEAD-YAP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein K6-linked Ubiquitination ISG15 Transferase Activity Regulation Of TORC1 Signaling Vesicle Transport Along Actin Filament ISG15-protein Conjugation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Catabolic Process Regulation Of TOR Signaling Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Protein Autoubiquitination Positive Regulation Of Non-canonical Wnt Signaling Pathway Protein K63-linked Ubiquitination Filopodium Tip Protein K27-linked Ubiquitination Translation Regulator Activity Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity TOR Signaling Positive Regulation Of Catabolic Process Negative Regulation Of TOR Signaling Cytoplasmic Stress Granule Nucleus Regulation Of Non-canonical Wnt Signaling Pathway Cellular Response To Interferon-beta	Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Protein Modification Process Protein Ubiquitination Cellular Response To Nitrogen Starvation Cytosol Ubiquitin Protein Ligase Binding Cellular Response To Nutrient Levels Catabolic Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Phosphatidylethanolamine Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Response To Nutrient Levels Mitophagy Response To Stress Cellular Response To Stress Positive Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Cytoplasm Cellular Response To Starvation Autophagosome Organization Macromolecule Metabolic Process Protein K48-linked Ubiquitination Autophagy Of Mitochondrion Regulation Of Protein Ubiquitination Nucleus Regulation Of Canonical NF-kappaB Signal Transduction Response To Virus Proteolysis Response To Starvation Vacuole Organization Positive Regulation Of Protein Polyubiquitination Autophagosome Assembly TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Defense Response To Other Organism Negative Regulation Of TORC1 Signaling Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Protein Ubiquitination PML Body Protein K63-linked Ubiquitination Macroautophagy
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