TRIM3 and ROPN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM3	ROPN1
Description		tripartite motif containing 3	rhophilin associated tail protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Dendrite Cell Projection	Nucleus Cytoplasm Cilium Motile Cilium Cell Projection
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Toll-like Receptor Signaling Pathway Nervous System Development Protein Transport Protein Ubiquitination Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination	Flagellated Sperm Motility Cilium Organization Sperm Capacitation Protein Localization To Cilium
Pathways		Interferon gamma signaling	RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS		Malaria ( 31844061)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Household income ( 31844048) Household income (MTAG) ( 31844048)
Interacting Genes		34 interacting genes: ACTN4 ASL CDKN1A CEP70 CSNK1D CSNK1E DNMT1 FXR1 FXR2 KCTD7 KIF21B LNX1 LRRC8E MYO5A MYO5B ROPN1 TEAD1 TEAD2 TNFAIP3 TPTEP2-CSNK1E TRIM21 TSC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2G2 UBE2K UBE2U UBE2W UBE2Z USP32	50 interacting genes: AKAIN1 AKAP14 AKAP3 AKAP5 AKAP7 AP1M1 BTBD16 CDC37 CEP57L1 CKS1B CNST DBF4B ERCC3 FAM110A FAM153A FAM153B FAM161A FAM90A1 GNL3L GPKOW HNRNPUL1 KIAA0753 KIF9 LENG1 LMO4 LNX1 LNX2 NTAQ1 PICK1 PKP2 POLR3C PRDM6 PRKAA1 PSMA1 RHPN1 RTP5 SDCBP SERTAD1 SORBS3 SPA17 SPG21 SYTL4 TRIM3 TSGA10IP TSHZ3 TSNAXIP1 TULP3 UBE2W VPS33A XKR3
Entrez ID		10612	54763
HPRD ID		05690	15269
Ensembl ID		ENSG00000110171	ENSG00000065371
Uniprot IDs		B7Z5Y8 O75382	A0A140VKB2 Q9HAT0
PDB IDs		7O0B 7QRW 8AMR
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process ATP Binding Proteolysis Involved In Protein Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Nucleotide Binding Protein Monoubiquitination Macromolecule Catabolic Process Protein K11-linked Ubiquitination Protein Metabolic Process TEAD-YAP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein K6-linked Ubiquitination ISG15 Transferase Activity Regulation Of TORC1 Signaling Vesicle Transport Along Actin Filament ISG15-protein Conjugation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Catabolic Process Regulation Of TOR Signaling Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Protein Autoubiquitination Positive Regulation Of Non-canonical Wnt Signaling Pathway Protein K63-linked Ubiquitination Filopodium Tip Protein K27-linked Ubiquitination Translation Regulator Activity Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity TOR Signaling Positive Regulation Of Catabolic Process Negative Regulation Of TOR Signaling Cytoplasmic Stress Granule Nucleus Regulation Of Non-canonical Wnt Signaling Pathway Cellular Response To Interferon-beta	Protein Kinase A Binding Protein Binding Protein Kinase A Regulatory Subunit Binding
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