TRIM3 and LRRC8E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM3	LRRC8E
Description		tripartite motif containing 3	leucine rich repeat containing 8 VRAC subunit E
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Dendrite Cell Projection	Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Protein Polyubiquitination Toll-like Receptor Signaling Pathway Nervous System Development Protein Transport Protein Ubiquitination Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination	Monoatomic Ion Transport Cell Volume Homeostasis Aspartate Transmembrane Transport Monoatomic Ion Transmembrane Transport Cellular Response To Osmotic Stress Monoatomic Anion Transmembrane Transport Cyclic-GMP-AMP Transmembrane Import Across Plasma Membrane
Pathways		Interferon gamma signaling	Miscellaneous transport and binding events
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Malaria ( 31844061)
Interacting Genes		34 interacting genes: ACTN4 ASL CDKN1A CEP70 CSNK1D CSNK1E DNMT1 FXR1 FXR2 KCTD7 KIF21B LNX1 LRRC8E MYO5A MYO5B ROPN1 TEAD1 TEAD2 TNFAIP3 TPTEP2-CSNK1E TRIM21 TSC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2G2 UBE2K UBE2U UBE2W UBE2Z USP32	7 interacting genes: FBXO7 GPSM2 LNX2 NUTM1 SAMD4B TRIM2 TRIM3
Entrez ID		10612	80131
HPRD ID		05690	08670
Ensembl ID		ENSG00000110171	ENSG00000171017
Uniprot IDs		B7Z5Y8 O75382	Q6NSJ5
PDB IDs		7O0B 7QRW 8AMR
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process ATP Binding Proteolysis Involved In Protein Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Nucleotide Binding Protein Monoubiquitination Macromolecule Catabolic Process Protein K11-linked Ubiquitination Protein Metabolic Process TEAD-YAP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein K6-linked Ubiquitination ISG15 Transferase Activity Regulation Of TORC1 Signaling Vesicle Transport Along Actin Filament ISG15-protein Conjugation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Catabolic Process Regulation Of TOR Signaling Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Protein Autoubiquitination Positive Regulation Of Non-canonical Wnt Signaling Pathway Protein K63-linked Ubiquitination Filopodium Tip Protein K27-linked Ubiquitination Translation Regulator Activity Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity TOR Signaling Positive Regulation Of Catabolic Process Negative Regulation Of TOR Signaling Cytoplasmic Stress Granule Nucleus Regulation Of Non-canonical Wnt Signaling Pathway Cellular Response To Interferon-beta	Ubiquitin-protein Transferase Activity Macromolecule Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteasomal Protein Catabolic Process Neural Precursor Cell Proliferation Lateral Cell Cortex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Lewy Body Core Cell Cortex Region Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Maintenance Of Centrosome Location Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly Post-translational Protein Modification Regulation Of Protein Localization To Cell Cortex
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