CENPA and AURKB

Number of citations of the paper that reports this interaction (PMID 11756469)
69

Data Source:
HPRD (in vitro)

		CENPA	AURKB
Gene Name		centromere protein A	aurora kinase B
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleosome Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Cytosol	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleosome Assembly Viral Process CENP-A Containing Nucleosome Assembly Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AURKB AURKC DIAPH1 DIAPH2 HIST1H3C HIST1H4F PARP1 PARP2	48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1
Entrez ID		1058	9212
HPRD ID		00313	05397
Ensembl ID		ENSG00000115163	ENSG00000178999
Uniprot IDs		P49450	Q96GD4
PDB IDs		3AN2 3NQJ 3NQU 3R45	4AF3
Enriched GO Terms of Interacting Partners?		Cellular Macromolecular Complex Assembly Protein Complex Assembly Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Cellular Protein Complex Assembly DNA Replication-dependent Nucleosome Assembly Spindle Midzone Assembly Cytokinesis Attachment Of Spindle Microtubules To Kinetochore Organelle Organization Cellular Component Assembly DNA Methylation On Cytosine Chromosome Organization Chromatin Silencing At RDNA Histone-serine Phosphorylation Mitotic Spindle Assembly Protein ADP-ribosylation Chromatin Organization Chromatin Silencing Positive Regulation Of Cytokinesis Histone Phosphorylation Actin Filament Polymerization Mitotic Spindle Organization Regulation Of Cytokinesis Microtubule Anchoring DNA Methylation Base-excision Repair Histone Modification DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Cytoskeleton Organization Cell Division Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Actin Polymerization Or Depolymerization Spindle Assembly DNA Modification Protein Polymerization Gene Silencing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Peptidyl-serine Phosphorylation Nucleosome Assembly Positive Regulation Of Cell Division Spindle Organization Chromatin Modification Chromatin Assembly	Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly	allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		annotated bca centromere chromosomes commercially consequent dfs embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly	allele birc5 cdca8 consortium contribution cpc european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?		division