CENPA and DIAPH2

Number of citations of the paper that reports this interaction (PMID 15085137)
53

Data Source:
HPRD (two hybrid, in vivo)

		CENPA	DIAPH2
Gene Name		centromere protein A	diaphanous-related formin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleosome Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Cytosol	Nucleolus Mitochondrion Early Endosome Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity	Actin Binding Receptor Binding Rho GTPase Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleosome Assembly Viral Process CENP-A Containing Nucleosome Assembly Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region	Cytokinesis Multicellular Organismal Development Female Gamete Generation Actin Filament Polymerization Oogenesis
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AURKB AURKC DIAPH1 DIAPH2 HIST1H3C HIST1H4F PARP1 PARP2	6 interactors: APBB1 CDC42 CENPA NCKIPSD RHOD TCERG1
Entrez ID		1058	1730
HPRD ID		00313	02117
Ensembl ID		ENSG00000115163	ENSG00000147202
Uniprot IDs		P49450	O60879 Q17R91
PDB IDs		3AN2 3NQJ 3NQU 3R45
Enriched GO Terms of Interacting Partners?		Cellular Macromolecular Complex Assembly Protein Complex Assembly Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Cellular Protein Complex Assembly DNA Replication-dependent Nucleosome Assembly Spindle Midzone Assembly Cytokinesis Attachment Of Spindle Microtubules To Kinetochore Organelle Organization Cellular Component Assembly DNA Methylation On Cytosine Chromosome Organization Chromatin Silencing At RDNA Histone-serine Phosphorylation Mitotic Spindle Assembly Protein ADP-ribosylation Chromatin Organization Chromatin Silencing Positive Regulation Of Cytokinesis Histone Phosphorylation Actin Filament Polymerization Mitotic Spindle Organization Regulation Of Cytokinesis Microtubule Anchoring DNA Methylation Base-excision Repair Histone Modification DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Cytoskeleton Organization Cell Division Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Actin Polymerization Or Depolymerization Spindle Assembly DNA Modification Protein Polymerization Gene Silencing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Peptidyl-serine Phosphorylation Nucleosome Assembly Positive Regulation Of Cell Division Spindle Organization Chromatin Modification Chromatin Assembly	Cytoskeleton Organization Actin Filament Bundle Assembly Cellular Protein Localization Adherens Junction Organization Organelle Organization Negative Regulation Of Thymidylate Synthase Biosynthetic Process Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of DNA Metabolic Process Protein Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Establishment Of Localization In Cell Actin Filament Branching Submandibular Salivary Gland Formation Establishment Or Maintenance Of Cell Polarity Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Regulation Of Cell-substrate Adhesion Cell-cell Junction Organization Cellular Localization Establishment Of Golgi Localization Positive Regulation Of Metalloenzyme Activity Phagocytosis Fc Receptor Signaling Pathway Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Cell Projection Assembly Regulation Of Protein Heterodimerization Activity Actin Filament Organization Keratinocyte Development Regulation Of Synapse Structural Plasticity Establishment Of Organelle Localization Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Pseudopodium Assembly Nuclear Migration Cardiac Conduction System Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Golgi Localization Axon Guidance Filopodium Assembly Organelle Localization Protein Targeting Intracellular Transport Hair Follicle Placode Formation Macrophage Differentiation NLS-bearing Protein Import Into Nucleus
Tagcloud ?		annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly
Tagcloud (Difference) ?		annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly
Tagcloud (Intersection) ?