CENPA and PARP2

Number of citations of the paper that reports this interaction (PMID 12217960)
17

Data Source:
HPRD (in vivo)

		CENPA	PARP2
Gene Name		centromere protein A	poly (ADP-ribose) polymerase 2
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleosome Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleosome Assembly Viral Process CENP-A Containing Nucleosome Assembly Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region	DNA Repair Base-excision Repair Protein ADP-ribosylation Extrinsic Apoptotic Signaling Pathway
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AURKB AURKC DIAPH1 DIAPH2 HIST1H3C HIST1H4F PARP1 PARP2	6 interactors: BUB3 CASP8 CENPA CENPB PARP1 XRCC1
Entrez ID		1058	10038
HPRD ID		00313	09660
Ensembl ID		ENSG00000115163	ENSG00000129484
Uniprot IDs		P49450	Q9UGN5
PDB IDs		3AN2 3NQJ 3NQU 3R45	3KCZ 3KJD
Enriched GO Terms of Interacting Partners?		Cellular Macromolecular Complex Assembly Protein Complex Assembly Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Cellular Protein Complex Assembly DNA Replication-dependent Nucleosome Assembly Spindle Midzone Assembly Cytokinesis Attachment Of Spindle Microtubules To Kinetochore Organelle Organization Cellular Component Assembly DNA Methylation On Cytosine Chromosome Organization Chromatin Silencing At RDNA Histone-serine Phosphorylation Mitotic Spindle Assembly Protein ADP-ribosylation Chromatin Organization Chromatin Silencing Positive Regulation Of Cytokinesis Histone Phosphorylation Actin Filament Polymerization Mitotic Spindle Organization Regulation Of Cytokinesis Microtubule Anchoring DNA Methylation Base-excision Repair Histone Modification DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Cytoskeleton Organization Cell Division Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Actin Polymerization Or Depolymerization Spindle Assembly DNA Modification Protein Polymerization Gene Silencing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Peptidyl-serine Phosphorylation Nucleosome Assembly Positive Regulation Of Cell Division Spindle Organization Chromatin Modification Chromatin Assembly	Macrophage Differentiation Base-excision Repair Myeloid Leukocyte Differentiation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Regulation Of Growth Rate Protein Poly-ADP-ribosylation TRAIL-activated Apoptotic Signaling Pathway
Tagcloud ?		annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly	abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp1 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 tnks2 valuable
Tagcloud (Difference) ?		annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly	abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp1 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 tnks2 valuable
Tagcloud (Intersection) ?