CENPA and H3C3

Number of citations of the paper that reports this interaction (PubMedID 15282608)
0

Data Source:
HPRD (in vitro)

		CENPA	H3C3
Description		centromere protein A	H3 clustered histone 3
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleosome Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol CENP-A Containing Nucleosome CENP-A Containing Chromatin	Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Cadherin Binding Protein Heterodimerization Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis CENP-A Containing Chromatin Assembly Cell Division Kinetochore Assembly Protein Localization To CENP-A Containing Chromatin Protein Localization To Chromosome, Centromeric Region	Chromatin Organization Nucleosome Assembly Gene Expression Telomere Organization Epigenetic Regulation Of Gene Expression
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2	9 interacting genes: ASF1A ASF1B CBX1 CENPA DAXX DNAJC9 PHF1 RIOX2 TRIM24
Entrez ID		1058	8352
HPRD ID		00313	11906
Ensembl ID		ENSG00000115163	ENSG00000287080
Uniprot IDs		P49450	P68431
PDB IDs		3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM 7D20 7PII 7R5R 7U46 7U47 7U4D 7YWX 7YYH 9GXA	1CS9 1CT6 1O9S 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CO0 2CV5 2FSA 2KWJ 2KWK 2L75 2LBM 2LGG 2M0O 2NDF 2NDG 2OQ6 2OT7 2OX0 2RI7 2RR4 2UXN 2V85 2V89 2VNF 2VPG 2X0L 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3FDT 3KMT 3KQI 3LQI 3LQJ 3MP1 3O34 3O35 3O37 3QJ6 3RIG 3RIY 3SOU 3SOW 3U31 3U3D 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3X1S 3X1T 3X1U 3X1V 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4C1Q 4F4U 4F56 4FWF 4HON 4I51 4L7X 4LK9 4LKA 4LLB 4LXL 4N4H 4QBQ 4QBR 4QBS 4TN7 4U68 4UP0 4UY4 4X3K 4Y6L 4YHP 4YHZ 4YM5 4YM6 4Z0R 4Z2M 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5B24 5B2I 5B2J 5B31 5C11 5C13 5C3I 5CPI 5CPJ 5CPK 5D6Y 5DAH 5FB0 5FB1 5FFV 5GH9 5GSE 5GSU 5GT0 5GT3 5GTC 5H6Q 5H6R 5HJB 5HJC 5HJD 5HYN 5IQL 5J3V 5J9S 5JHN 5JIN 5JIY 5JJ0 5JRG 5KJH 5KJI 5KKL 5LUG 5M5G 5MR8 5NNC 5NND 5OY3 5SVX 5SVY 5SZB 5SZC 5T0K 5T0M 5T1G 5T1I 5T8R 5TBN 5TDR 5TDW 5U2J 5V21 5V22 5VA6 5VAB 5VGE 5VNB 5WFC 5WLE 5WVO 5WXG 5WXH 5WYI 5X60 5XF3 5XF4 5XF5 5XFQ 5XFR 5XNV 5XTZ 5Y0C 5Y0D 5Y20 5Y2F 5Z23 5Z30 6AXJ 6AZE 6BHD 6BHE 6BHG 6BHH 6BHI 6D07 6D08 6E83 6E86 6F6D 6HKT 6HTS 6IEU 6IIS 6IIT 6IPU 6IQ4 6JOU 6JR0 6JR1 6JXD 6K1I 6K1J 6K1K 6KE9 6KVD 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6LS6 6LSD 6M3V 6M44 6M4D 6M4G 6M4H 6MIL 6MIM 6MIN 6MIO 6MIQ 6PA1 6PAG 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T90 6T93 6UPK 6UPL 6USJ 6V2H 6V2K 6V3N 6V41 6V92 6VIL 6WAV 6WW4 6YIF 6YIH 6YOV 7BWD 7C0M 7CCQ 7CCR 7CFP 7CFQ 7COW 7D1Z 7DBP 7E8D 7EBK 7K5X 7K5Y 7K60 7K61 7K63 7KLR 7LBK 7LBO 7LBP 7LBQ 7LYA 7LYB 7LYC 7MJU 7NL0 7SCY 7SCZ 7TD5 7U0G 7U0I 7U0J 7V6Q 7V90 7V96 7V9C 7V9J 7V9K 7V9S 7VA4 7VZ4 7W9V 7X57 7X58 7XD1 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y5U 7Y5V 7Y5W 7Y60 7Y61 7Y7I 7Y8R 7YOZ 7YQK 7ZI4 8DK5 8DS8 8EVG 8EVH 8EVI 8EVJ 8GE0 8GRM 8GUI 8GUJ 8GUK 8H0V 8H0W 8H1T 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HLY 8HMX 8I60 8IEG 8IEJ 8IHL 8IIY 8IIZ 8IJ0 8IQF 8IQG 8J6S 8J6T 8JBX 8JCC 8JCD 8JHF 8JHG 8JL9 8JLA 8JND 8JNE 8JNF 8KCY 8KD1 8KE0 8OFF 8OO7 8OOA 8OOP 8OOS 8OSJ 8OSK 8OSL 8OTS 8OTT 8OX0 8OX1 8Q36 8Q3E 8Q3M 8Q3X 8QKT 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8SPS 8SPU 8SWI 8SYP 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8VMI 8VML 8VNV 8W9D 8W9E 8W9F 8WG5 8X15 8X19 8X1C 8XBT 8XBU 8XBW 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YJF 8YJM 8YNY 8YTI 8YV8 9FGQ 9FH9 9J8M 9J8N 9J8O
Enriched GO Terms of Interacting Partners?		Chromosome Protein Localization To Chromosome NAD+-protein-serine ADP-ribosyltransferase Activity Protein Localization To Organelle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Localization To Chromatin Chromosome Passenger Complex Mitotic Spindle Midzone Assembly Organelle Organization Cellular Response To UV Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity Spindle Midzone Assembly NAD+-protein-aspartate ADP-ribosyltransferase Activity Chromatin Remodeling Cellular Response To Light Stimulus Negative Regulation Of CGAS/STING Signaling Pathway Protein Poly-ADP-ribosylation Telomere Organization NAD+-protein Mono-ADP-ribosyltransferase Activity Chromatin Organization Post-translational Protein Modification Decidualization DNA Repair-dependent Chromatin Remodeling DNA Modification Response To UV NAD+ Poly-ADP-ribosyltransferase Activity Chromosome, Centromeric Region Protein Serine/threonine/tyrosine Kinase Activity Spindle Midzone Kinetochore Cellular Response To Radiation Nucleolus Actin Filament Polymerization Nucleosome Binding Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Immune System Process Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Spindle Microtubule Site Of DNA Damage Positive Regulation Of Cytokinesis Intracellular Protein Localization Nucleus Spindle Positive Regulation Of Cell Cycle Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity	Chromatin Organization Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone Binding Nucleoplasm Chromatin Binding Protein-DNA Complex Assembly DNA Replication-dependent Chromatin Assembly Histone Chaperone Activity Histone Methyltransferase Binding Chromosome, Centromeric Region DNA Repair-dependent Chromatin Remodeling Pericentric Heterochromatin Nucleus Protein-containing Complex Assembly Protein Localization To Chromatin Protein-containing Complex Organization CENP-A Containing Chromatin Heat Shock Protein Binding Histone H3K23ac Reader Activity P53 Binding Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Site Of Double-strand Break Protein Localization To Chromosome Chromatin Peptidyl-histidine Dioxygenase Activity Cellular Response To Sodium Arsenite Perichromatin Fibrils Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Response To Sodium Arsenite Cellular Response To Salt Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone H3K36me3 Reader Activity Cellular Component Assembly Negative Regulation Of RNA Metabolic Process Male Pronucleus Histone H3K4 Demethylase Activity Chromosome Histone H3K36 Demethylase Activity CENP-A Containing Chromatin Assembly Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Vitamin D Receptor Signaling Pathway
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