CENPA and HJURP

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, affinity chromatography technology)

		CENPA	HJURP
Description		centromere protein A	Holliday junction recognition protein
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleosome Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol CENP-A Containing Nucleosome CENP-A Containing Chromatin	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	DNA Binding Protein Binding Histone Binding Identical Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis CENP-A Containing Chromatin Assembly Cell Division Kinetochore Assembly Protein Localization To CENP-A Containing Chromatin Protein Localization To Chromosome, Centromeric Region	Chromosome Segregation CENP-A Containing Chromatin Assembly Regulation Of Protein-containing Complex Assembly Regulation Of DNA Binding
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Deposition of new CENPA-containing nucleosomes at the centromere Cyclin A/B1/B2 associated events during G2/M transition
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Hair greying ( 26926045) Headache ( 29397368) Migraine ( 27322543) Migraine without aura ( 27322543) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2	7 interacting genes: CDK1 CENPA H4C1 IMMT KPNA4 OIP5 STT3A
Entrez ID		1058	55355
HPRD ID		00313	10912
Ensembl ID		ENSG00000115163	ENSG00000123485
Uniprot IDs		P49450	Q8NCD3
PDB IDs		3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM 7D20 7PII 7R5R 7U46 7U47 7U4D 7YWX 7YYH 9GXA	3R45
Enriched GO Terms of Interacting Partners?		Chromosome Protein Localization To Chromosome NAD+-protein-serine ADP-ribosyltransferase Activity Protein Localization To Organelle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Localization To Chromatin Chromosome Passenger Complex Mitotic Spindle Midzone Assembly Organelle Organization Cellular Response To UV Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity Spindle Midzone Assembly NAD+-protein-aspartate ADP-ribosyltransferase Activity Chromatin Remodeling Cellular Response To Light Stimulus Negative Regulation Of CGAS/STING Signaling Pathway Protein Poly-ADP-ribosylation Telomere Organization NAD+-protein Mono-ADP-ribosyltransferase Activity Chromatin Organization Post-translational Protein Modification Decidualization DNA Repair-dependent Chromatin Remodeling DNA Modification Response To UV NAD+ Poly-ADP-ribosyltransferase Activity Chromosome, Centromeric Region Protein Serine/threonine/tyrosine Kinase Activity Spindle Midzone Kinetochore Cellular Response To Radiation Nucleolus Actin Filament Polymerization Nucleosome Binding Protein Modification Process Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Immune System Process Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Spindle Microtubule Site Of DNA Damage Positive Regulation Of Cytokinesis Intracellular Protein Localization Nucleus Spindle Positive Regulation Of Cell Cycle Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity	Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome CENP-A Containing Chromatin Assembly CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Protein Localization To Organelle Chromatin Remodeling Chromatin Organization Protein Localization To Chromatin Chromosome Organization Pronuclear Fusion CENP-A Containing Chromatin Structural Constituent Of Chromatin Cell Division Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Response To Hydrogen Peroxide Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Oligosaccharyl Transferase Activity Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Microtubule Cytoskeleton Organization Involved In Mitosis Cyclin-dependent Protein Kinase Activity Nucleosome Pericentric Heterochromatin Organization CENP-A Recruiting Complex Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Response To Reactive Oxygen Species Thymidine Biosynthetic Process Chromosome Chromosome, Centromeric Region Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Golgi Disassembly Nuclear DNA Replication Chromosome, Telomeric Region Histone Kinase Activity Dopamine Secretion Mitochondrial Crista Junction Thymidine Metabolic Process MICOS Complex Intracellular Protein Localization Catecholamine Secretion Positive Regulation Of Mitotic Sister Chromatid Segregation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Oligosaccharyltransferase Complex A NLS-dependent Protein Nuclear Import Complex
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