CENPA and DIAPH1

Number of citations of the paper that reports this interaction (PMID 15085137)
53

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CENPA	DIAPH1
Gene Name		centromere protein A	diaphanous-related formin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleosome Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Cytosol	Cytoplasm Ruffle Membrane Neuron Projection Mitotic Spindle
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity	Actin Binding Receptor Binding Protein Binding Profilin Binding Rho GTPase Binding Identical Protein Binding Ion Channel Binding Poly(A) RNA Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nucleosome Assembly Viral Process CENP-A Containing Nucleosome Assembly Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Filament Polymerization Positive Regulation Of Cell Migration Neuron Projection Development Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Histamine
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AURKB AURKC DIAPH1 DIAPH2 HIST1H3C HIST1H4F PARP1 PARP2	15 interactors: APBB1 BAIAP2 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A RAC1 RHOA RHOC TCERG1 WBP4 XPO6
Entrez ID		1058	1729
HPRD ID		00313	03670
Ensembl ID		ENSG00000115163	ENSG00000131504
Uniprot IDs		P49450	O60610 Q6URC4
PDB IDs		3AN2 3NQJ 3NQU 3R45
Enriched GO Terms of Interacting Partners?		Cellular Macromolecular Complex Assembly Protein Complex Assembly Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Cellular Protein Complex Assembly DNA Replication-dependent Nucleosome Assembly Spindle Midzone Assembly Cytokinesis Attachment Of Spindle Microtubules To Kinetochore Organelle Organization Cellular Component Assembly DNA Methylation On Cytosine Chromosome Organization Chromatin Silencing At RDNA Histone-serine Phosphorylation Mitotic Spindle Assembly Protein ADP-ribosylation Chromatin Organization Chromatin Silencing Positive Regulation Of Cytokinesis Histone Phosphorylation Actin Filament Polymerization Mitotic Spindle Organization Regulation Of Cytokinesis Microtubule Anchoring DNA Methylation Base-excision Repair Histone Modification DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance Cytoskeleton Organization Cell Division Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Actin Polymerization Or Depolymerization Spindle Assembly DNA Modification Protein Polymerization Gene Silencing Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Peptidyl-serine Phosphorylation Nucleosome Assembly Positive Regulation Of Cell Division Spindle Organization Chromatin Modification Chromatin Assembly	Regulation Of Cell Morphogenesis Neuron Projection Development Cell Cycle Regulation Of Cellular Component Organization Neuron Development Neuron Projection Morphogenesis Cell Cycle Process Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Cell Projection Morphogenesis Skeletal Muscle Satellite Cell Migration Cell Part Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Cell Morphogenesis Positive Regulation Of DNA Metabolic Process Nervous System Development Regulation Of Cell Shape Neurogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Anatomical Structure Morphogenesis Cell Development Locomotion Cell Migration Cell Motility Regulation Of Cell Cycle Chemotaxis Organelle Organization Mitotic Cell Cycle Process Response To External Stimulus Response To Stress Mitotic Cell Cycle Protein Localization Cell Cycle Arrest Positive Regulation Of Intracellular Signal Transduction Cellular Protein Localization Cell Division Regulation Of Cell Development Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Cell Cycle Process Negative Regulation Of Neuron Differentiation Wound Healing, Spreading Of Cells
Tagcloud ?		annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly	5q 5q31 aberrantly abnormality autonomous cd14 del deregulated formin granulocytes hematologic heterozygosity heterozygous hypersensitive innate knockout lenalidomide lineages lipopolysaccharide mdia1 mdss mechanistically messenger mimicking neoplasm polymerization rescued toll underscore
Tagcloud (Difference) ?		annotated bca centromere chromosomes commercially consequent dfs division embedded evaluating exploration hallmark hazards ihc instability kaplan km mammaprint meier mgism microarrays nuclei paraffin scored segregation signature stained triplicate visibly	5q 5q31 aberrantly abnormality autonomous cd14 del deregulated formin granulocytes hematologic heterozygosity heterozygous hypersensitive innate knockout lenalidomide lineages lipopolysaccharide mdia1 mdss mechanistically messenger mimicking neoplasm polymerization rescued toll underscore
Tagcloud (Intersection) ?