CNTFR and LIFR

Number of citations of the paper that reports this interaction (PubMedID 11285233)
75

Data Source:
HPRD (in vitro)

		CNTFR	LIFR
Description		ciliary neurotrophic factor receptor	LIF receptor subunit alpha
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex Side Of Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding Interleukin-11 Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding
	Biological Process	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Interleukin-11-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway Motor Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling
Drugs
Diseases			Stuve-Wiedemann syndrome
GWAS		Blood protein levels ( 30072576) Physiological traits ( 31902109)	Blood protein levels ( 30072576) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Pursuit maintenance gain ( 29064472) Ulcerative colitis ( 26192919)
Interacting Genes		9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1	12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6
Entrez ID		1271	3977
HPRD ID		00348	01048
Ensembl ID		ENSG00000122756	ENSG00000113594
Uniprot IDs		P26992	A8K1Z4 P42702
PDB IDs		1UC6 8D74 8D7E 8D7H 8D7R	3E0G 8D6A 8D74 8D7R 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor Receptor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Leukemia Inhibitory Factor Receptor Activity CRLF-CLCF1 Complex Oncostatin-M Receptor Activity Negative Regulation Of Neuron Apoptotic Process Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cytokine Binding Oncostatin-M-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Cell Population Proliferation Cytokine Activity Interleukin-6 Receptor Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Neuron Apoptotic Process Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Regulation Of Cell Population Proliferation Regulation Of Astrocyte Differentiation Receptor Complex Positive Regulation Of Glial Cell Differentiation Regulation Of Adaptive Immune Response Positive Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Growth Factor Binding Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Activation Positive Regulation Of Immune Response Extracellular Region Regulation Of Leukocyte Proliferation Positive Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Gliogenesis Regulation Of Apoptotic Process Regulation Of Glial Cell Differentiation Regulation Of Programmed Cell Death Extracellular Space Positive Regulation Of Lymphocyte Activation External Side Of Plasma Membrane Interleukin-27 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Lead Ion Binding	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Phosphorylation Leukemia Inhibitory Factor Receptor Binding Cell Development Regulation Of Phosphorus Metabolic Process Ciliary Neurotrophic Factor Receptor Complex Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Protein Modification Process Interleukin-11 Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Binding Enzyme-linked Receptor Protein Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Metabolic Process Cytokine Receptor Activity Regulation Of Inflammatory Response Response To Epidermal Growth Factor Ciliary Neurotrophic Factor Receptor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Interleukin-6 Receptor Binding Interleukin-11-mediated Signaling Pathway Regulation Of Defense Response Negative Regulation Of Neutrophil Activation Epidermal Growth Factor Receptor Signaling Pathway Cytokine Activity Muscle Organ Morphogenesis Negative Regulation Of Hormone Secretion Regulation Of Multicellular Organismal Process ERBB Signaling Pathway
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