CNTFR and CLCF1

Number of citations of the paper that reports this interaction (PubMedID 11285233)
75

Data Source:
HPRD (in vitro, in vivo)

		CNTFR	CLCF1
Description		ciliary neurotrophic factor receptor	cardiotrophin like cytokine factor 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex Side Of Membrane	Extracellular Region Extracellular Space CRLF-CLCF1 Complex CNTFR-CLCF1 Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding Interleukin-11 Binding	Signaling Receptor Binding Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Activity Receptor Ligand Activity
	Biological Process	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Interleukin-11-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway Motor Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Astrocyte Differentiation Cell Surface Receptor Signaling Pathway Via STAT
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases			Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Blood protein levels ( 30072576) Physiological traits ( 31902109)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1	5 interacting genes: CNTFR CRLF1 S100A1 S100A6 S100P
Entrez ID		1271	23529
HPRD ID		00348	09643
Ensembl ID		ENSG00000122756	ENSG00000175505
Uniprot IDs		P26992	Q9UBD9
PDB IDs		1UC6 8D74 8D7E 8D7H 8D7R	8D7H 8D7R
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor Receptor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Leukemia Inhibitory Factor Receptor Activity CRLF-CLCF1 Complex Oncostatin-M Receptor Activity Negative Regulation Of Neuron Apoptotic Process Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cytokine Binding Oncostatin-M-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Cell Population Proliferation Cytokine Activity Interleukin-6 Receptor Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Neuron Apoptotic Process Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Regulation Of Cell Population Proliferation Regulation Of Astrocyte Differentiation Receptor Complex Positive Regulation Of Glial Cell Differentiation Regulation Of Adaptive Immune Response Positive Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Growth Factor Binding Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Activation Positive Regulation Of Immune Response Extracellular Region Regulation Of Leukocyte Proliferation Positive Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Gliogenesis Regulation Of Apoptotic Process Regulation Of Glial Cell Differentiation Regulation Of Programmed Cell Death Extracellular Space Positive Regulation Of Lymphocyte Activation External Side Of Plasma Membrane Interleukin-27 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Lead Ion Binding	Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Cell Population Proliferation Calcium-dependent Protein Binding Regulation Of Motor Neuron Apoptotic Process S100 Protein Binding Cytokine Binding Regulation Of Cell Population Proliferation Cytokine Receptor Activity Cytokine-mediated Signaling Pathway Interleukin-11 Receptor Activity Negative Regulation Of Neuron Apoptotic Process CNTFR-CLCF1 Complex Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Binding Regulation Of Oligodendrocyte Progenitor Proliferation Platelet Degranulation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Postsynaptic Specialization, Intracellular Component Cytoplasmic Side Of Plasma Membrane SH3 Domain Binding Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Interleukin-5-mediated Signaling Pathway Positive Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Protein Homodimerization Activity Calcium Ion Binding Ciliary Neurotrophic Factor Receptor Binding CRLF-CLCF1 Complex Synaptic Receptor Adaptor Activity Interleukin-11-mediated Signaling Pathway Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Brainstem Development Mitochondrial Crista Regulation Of Mast Cell Proliferation Signaling Receptor Activator Activity Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Histamine Transport Suckling Behavior
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