CNTFR and CRLF1

Number of citations of the paper that reports this interaction (PubMedID 10966616)
0

Data Source:
HPRD (in vitro, in vivo)

		CNTFR	CRLF1
Description		ciliary neurotrophic factor receptor	cytokine receptor like factor 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex Side Of Membrane	Extracellular Region Extracellular Space Cytosol External Side Of Plasma Membrane Receptor Complex CRLF-CLCF1 Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding Interleukin-11 Binding	Cytokine Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Interleukin-11-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway Motor Neuron Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process	Ureteric Bud Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions Interleukin-27 signaling
Drugs
Diseases			Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Blood protein levels ( 30072576) Physiological traits ( 31902109)	Blood protein levels ( 30072576) Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808)
Interacting Genes		9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1	2 interacting genes: CLCF1 CNTFR
Entrez ID		1271	9244
HPRD ID		00348	09177
Ensembl ID		ENSG00000122756	ENSG00000006016
Uniprot IDs		P26992	O75462
PDB IDs		1UC6 8D74 8D7E 8D7H 8D7R	8D7H
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor Receptor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Leukemia Inhibitory Factor Receptor Activity CRLF-CLCF1 Complex Oncostatin-M Receptor Activity Negative Regulation Of Neuron Apoptotic Process Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cytokine Binding Oncostatin-M-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Cell Population Proliferation Cytokine Activity Interleukin-6 Receptor Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Neuron Apoptotic Process Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Regulation Of Cell Population Proliferation Regulation Of Astrocyte Differentiation Receptor Complex Positive Regulation Of Glial Cell Differentiation Regulation Of Adaptive Immune Response Positive Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Growth Factor Binding Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Activation Positive Regulation Of Immune Response Extracellular Region Regulation Of Leukocyte Proliferation Positive Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Gliogenesis Regulation Of Apoptotic Process Regulation Of Glial Cell Differentiation Regulation Of Programmed Cell Death Extracellular Space Positive Regulation Of Lymphocyte Activation External Side Of Plasma Membrane Interleukin-27 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Lead Ion Binding	CNTFR-CLCF1 Complex Interleukin-11 Receptor Activity Signaling Receptor Binding Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Cytokine-mediated Signaling Pathway Interleukin-11 Binding Positive Regulation Of Isotype Switching To IgE Isotypes CRLF-CLCF1 Complex Ciliary Neurotrophic Factor Receptor Binding Interleukin-11-mediated Signaling Pathway Brainstem Development Suckling Behavior Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Astrocyte Differentiation Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Extrinsic Component Of Membrane Skeletal Muscle Organ Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Sex Differentiation Positive Regulation Of Isotype Switching Regulation Of Astrocyte Differentiation Regulation Of Isotype Switching Positive Regulation Of Glial Cell Differentiation Cytokine Binding Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of B Cell Proliferation Cytokine Receptor Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of B Cell Proliferation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Gliogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Glial Cell Differentiation Regulation Of Cell Population Proliferation Positive Regulation Of DNA Recombination Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Feeding Behavior Positive Regulation Of B Cell Activation Regulation Of Gliogenesis Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway
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