PPP2R2A and RRN3

Number of citations of the paper that reports this interaction (PubMedID 15004009)
51

Data Source:
BioGRID (pull down)

		PPP2R2A	RRN3
Description		protein phosphatase 2 regulatory subunit Balpha	RNA polymerase I transcription factor RRN3
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleoplasm Cytosol Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein-containing Complex Binding Tau Protein Binding Protein Phosphatase 2A Binding Enzyme-substrate Adaptor Activity	RNA Polymerase I Core Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Protein Binding RNA Polymerase Binding
	Biological Process	Protein Dephosphorylation Response To Morphine Regulation Of Chromosome Segregation	RNA Polymerase I Preinitiation Complex Assembly In Utero Embryonic Development DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Ribosome Biogenesis Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Homeostasis Of Number Of Cells Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription Initiation
Pathways		Initiation of Nuclear Envelope (NE) Reformation Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS		Declining hemoglobin trajectory in blood donors ( 33491795) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Height ( 23563607) Schizophrenia ( 28991256) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fruit consumption ( 32066663) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Serum metabolite levels ( 33031748) Triglyceride levels ( 32154731)
Interacting Genes		13 interacting genes: BRAF CHEK2 CREBBP GRIN1 GRIN2D MTOR NDRG1 PPP2CA PPP2R1A PPP2R1B RRN3 STRN3 TGFBR1	10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C
Entrez ID		5520	54700
HPRD ID		09223	12004
Ensembl ID		ENSG00000221914	ENSG00000085721
Uniprot IDs		A0A140VJT0 A0A590UJJ1 P63151	B7ZB55 F5H148 Q9NYV6
PDB IDs		3DW8 8SO0 8TTB 8TWE	7OBA
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Negative Regulation Of Hippo Signaling Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Signal Transduction Regulation Of Hippo Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Positive Regulation Of Stress Fiber Assembly Signal Transduction Negative Regulation Of Intracellular Signal Transduction NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Actin Filament Bundle Assembly NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Cellular Component Biogenesis Regulation Of Intracellular Signal Transduction Excitatory Chemical Synaptic Transmission Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Meiotic Sister Chromatid Cohesion Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Spindle Assembly Regulation Of Stress Fiber Assembly Regulation Of Cellular Response To Heat Vascular Endothelial Cell Response To Fluid Shear Stress Signal Transduction By P53 Class Mediator Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction INTAC Complex Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Amino Acid Regulation Of Signal Transduction By P53 Class Mediator Serine/threonine Protein Kinase Complex RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of RNA Metabolic Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Macromolecule Biosynthetic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Synaptic Transmission	Transcription By RNA Polymerase I RNA Polymerase Transcription Factor SL1 Complex DNA-templated Transcription Nucleolus RRNA Transcription Nucleoplasm Cyclin E1-CDK2 Complex RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Complex Nucleic Acid Metabolic Process RNA Metabolic Process Macromolecule Metabolic Process Fibrillar Center Nucleobase-containing Compound Metabolic Process DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex Cyclin-dependent Protein Kinase Holoenzyme Complex RRNA Metabolic Process Transcription Preinitiation Complex Assembly RNA Polymerase I Core Factor Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Negative Regulation Of Protein Localization To Nucleolus Nucleologenesis Nucleotidyltransferase Activity Telomere Maintenance Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Ribonucleoside Binding X Chromosome Telomere Organization Stereocilium Membrane RNA Polymerase I General Transcription Initiation Factor Activity Viral Translational Termination-reinitiation Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity
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