PPP2R2A and STRN3

Number of citations of the paper that reports this interaction (PubMedID 10681496)
29

Data Source:
HPRD (in vivo)

		PPP2R2A	STRN3
Description		protein phosphatase 2 regulatory subunit Balpha	striatin 3
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleoplasm Cytosol Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Membrane Dendrite Protein-containing Complex Neuronal Cell Body FAR/SIN/STRIPAK Complex Postsynapse
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein-containing Complex Binding Tau Protein Binding Protein Phosphatase 2A Binding Enzyme-substrate Adaptor Activity	Protein Binding Calmodulin Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding
	Biological Process	Protein Dephosphorylation Response To Morphine Regulation Of Chromosome Segregation	Negative Regulation Of Transcription By RNA Polymerase II Response To Estradiol Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Hippo Signaling Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Initiation of Nuclear Envelope (NE) Reformation Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
Diseases
GWAS		Declining hemoglobin trajectory in blood donors ( 33491795) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Height ( 23563607) Schizophrenia ( 28991256) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		13 interacting genes: BRAF CHEK2 CREBBP GRIN1 GRIN2D MTOR NDRG1 PPP2CA PPP2R1A PPP2R1B RRN3 STRN3 TGFBR1	10 interacting genes: CALM1 GABARAPL1 MOB1A NR3C1 PPP2R1A PPP2R1B PPP2R2A SIKE1 SLC2A4 TCEANC
Entrez ID		5520	29966
HPRD ID		09223	11613
Ensembl ID		ENSG00000221914	ENSG00000196792
Uniprot IDs		A0A140VJT0 A0A590UJJ1 P63151	Q13033
PDB IDs		3DW8 8SO0 8TTB 8TWE	4N6J 6AKL 6IUR 7K36
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Negative Regulation Of Hippo Signaling Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Signal Transduction Regulation Of Hippo Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Positive Regulation Of Stress Fiber Assembly Signal Transduction Negative Regulation Of Intracellular Signal Transduction NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Actin Filament Bundle Assembly NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Cellular Component Biogenesis Regulation Of Intracellular Signal Transduction Excitatory Chemical Synaptic Transmission Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Meiotic Sister Chromatid Cohesion Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Spindle Assembly Regulation Of Stress Fiber Assembly Regulation Of Cellular Response To Heat Vascular Endothelial Cell Response To Fluid Shear Stress Signal Transduction By P53 Class Mediator Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction INTAC Complex Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Amino Acid Regulation Of Signal Transduction By P53 Class Mediator Serine/threonine Protein Kinase Complex RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of RNA Metabolic Process Regulation Of Supramolecular Fiber Organization Positive Regulation Of Macromolecule Biosynthetic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Synaptic Transmission	Protein Phosphatase Type 2A Complex Protein Phosphatase Regulator Activity Meiotic Sister Chromatid Cohesion, Centromeric Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Meiotic Sister Chromatid Cohesion FAR/SIN/STRIPAK Complex Negative Regulation Of Hippo Signaling Cytosol Sister Chromatid Cohesion Regulation Of Hippo Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Nuclear Glucocorticoid Receptor Activity Meiotic Spindle Elongation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Serine/threonine Kinase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Spindle Assembly Protein Kinase Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Positive Regulation Of Programmed Cell Death Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Chromosome Segregation Positive Regulation Of Apoptotic Process Nuclear Receptor-mediated Corticosteroid Signaling Pathway Steroid Hormone Binding Positive Regulation Of Apoptotic Signaling Pathway Mitotic Sister Chromatid Separation Spindle Elongation Insulin-responsive Compartment Glucose Import In Response To Insulin Stimulus White Fat Cell Proliferation Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking Response To Cortisol Spindle Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Vesicle Negative Regulation Of Voltage-gated Calcium Channel Activity
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