DDX1 and NME7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DDX1	NME7
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 1	NME/NM23 family member 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cleavage Body TRNA-splicing Ligase Complex	Centrosome Ciliary Basal Body
	Molecular Function	DNA Binding Chromatin Binding Transcription Cofactor Activity RNA Helicase Activity Double-stranded RNA Binding Nuclease Activity Exonuclease Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Poly(A) Binding DNA/RNA Helicase Activity Poly(A) RNA Binding	Nucleoside Diphosphate Kinase Activity ATP Binding Metal Ion Binding
	Biological Process	Spliceosomal Complex Assembly Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Regulation Of Translational Initiation Multicellular Organismal Development Response To Virus DNA Duplex Unwinding Response To Exogenous DsRNA Nucleic Acid Phosphodiester Bond Hydrolysis	Epithelial Cilium Movement Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Determination Of Left/right Symmetry Brain Development Intraciliary Transport Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Left/right Pattern Formation
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 22479191) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Wilms tumor ( 22544364)	D-dimer levels ( 21502573) Venous thromboembolism ( 21980494 22672568)
Protein-Protein Interactions		8 interactors: APP ATM CSTF2 HNRNPK NDRG1 NME7 RELA YWHAQ	27 interactors: C1orf189 CCHCR1 CDC42EP2 CEP72 DDX1 FKBP6 FOSL1 GOLGA2 KIAA1598 KRT18 LNX1 MAP4K4 MYOT NAB2 NEFL NT5C2 OFD1 REL SYCE1 TCF4 TCHP TNIP1 TRIM27 TUFT1 YWHAQ ZBTB48 ZNF263
Entrez ID		1653	29922
HPRD ID		03158	11394
Ensembl ID		ENSG00000079785	ENSG00000143156
Uniprot IDs		A3RJH1 Q92499	Q9Y5B8
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process Nervous System Development MRNA Polyadenylation Positive Regulation Of Cell Cycle Process RNA Polyadenylation Brain Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Head Development Positive Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Neuron Apoptotic Process Signal Transduction Central Nervous System Development Neuron Death Response To Abiotic Stimulus Signaling MRNA Processing DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Communication MRNA 3'-end Processing Response To Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Acetaldehyde Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process RNA 3'-end Processing System Development Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Positive Regulation Of Schwann Cell Differentiation RNA Processing Cellular Response To Stimulus Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Collateral Sprouting In Absence Of Injury Regulation Of Schwann Cell Differentiation Nucleobase-containing Compound Metabolic Process Cell Activation Multicellular Organismal Development Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Response To Cobalamin Anatomical Structure Development Pre-B Cell Allelic Exclusion Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway	Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression Cell Cycle Response To Corticosterone Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Response To Mineralocorticoid Negative Regulation Of Transcription, DNA-templated Intermediate Filament Cytoskeleton Organization Negative Regulation Of Nucleic Acid-templated Transcription Organelle Organization Negative Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Intermediate Filament-based Process Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Golgi To Plasma Membrane CFTR Protein Transport Bone Mineralization Body Morphogenesis Developmental Process Transcription, DNA-templated Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Interleukin-2 Secretion Gamma-tubulin Complex Localization Catenin Import Into Nucleus Vitellogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Cellular Component Assembly Negative Regulation Of Viral Process Biomineral Tissue Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Neurofilament Bundle Assembly Ossification Regulation Of Cellular Component Organization Maintenance Of DNA Repeat Elements RNA Metabolic Process Intracellular Transport Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Regulation Of Cellular Component Size Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Secretion
Tagcloud ?		apply asp clcn7 complementation complementing disequilibrium erb ercc1 erythroblastic exo1 exonuclease gwas helicase inconsistent nominal perfect phosphoprotein prerequisite reexamined replicate replicating rs2844484 rs2857602 spp1 stringent swedish tmc6 tmc8 underscore	acentrosomal associates cdk5rap2 centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Difference) ?		apply asp clcn7 complementation complementing disequilibrium erb ercc1 erythroblastic exo1 exonuclease gwas helicase inconsistent nominal perfect phosphoprotein prerequisite reexamined replicate replicating rs2844484 rs2857602 spp1 stringent swedish tmc6 tmc8 underscore	acentrosomal associates cdk5rap2 centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Intersection) ?