DDX1 and HNRNPK

Number of citations of the paper that reports this interaction (PMID 12183465)
9

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		DDX1	HNRNPK
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 1	heterogeneous nuclear ribonucleoprotein K
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cleavage Body TRNA-splicing Ligase Complex	Nuclear Chromatin Podosome Nucleus Nucleoplasm Cytoplasm Focal Adhesion Membrane Cell Projection Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding Chromatin Binding Transcription Cofactor Activity RNA Helicase Activity Double-stranded RNA Binding Nuclease Activity Exonuclease Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Poly(A) Binding DNA/RNA Helicase Activity Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Single-stranded DNA Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Complex Assembly Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Regulation Of Translational Initiation Multicellular Organismal Development Response To Virus DNA Duplex Unwinding Response To Exogenous DsRNA Nucleic Acid Phosphodiester Bond Hydrolysis	MRNA Splicing, Via Spliceosome Transcription, DNA-templated RNA Processing Signal Transduction RNA Splicing Gene Expression Regulation Of Low-density Lipoprotein Particle Clearance Viral Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Chronic kidney disease ( 22479191) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Wilms tumor ( 22544364)
Protein-Protein Interactions		8 interactors: APP ATM CSTF2 HNRNPK NDRG1 NME7 RELA YWHAQ	107 interactors: ABI2 APBB1 AQP5 BTRC C6orf226 CBLB CCAR1 CCDC33 CDKN1A CEBPB CIRBP CNNM3 CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 EIF3F ELAVL1 FBXL18 FYN GFI1B GRAP2 GRB2 GZMA GZMK HCK HIST3H3 HMGB1 HNRNPA0 HNRNPD HNRNPL HNRNPLL ITK ITSN2 KHDRBS1 KHDRBS2 KHDRBS3 LYN MAPK10 MARK4 MATR3 NCK2 NEDD4 NPDC1 PABPC1 PCBP1 PCBP2 PCDHB14 PELI2 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A PRR3 PTBP1 QKI RALY RASD1 RBFOX2 RBM10 RBM3 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RNA18S5 RNA28S5 RTP5 SAFB SF1 SMAD3 SNRPA SORBS3 SPG7 SRC SREK1 SRRT SRSF3 SUMO1 SYNCRIP TBP TCERG1 TERF2IP TYK2 U2AF1 U2AF2 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 YWHAQ ZFC3H1 ZNF385C ZNF792 ZNRF2P1
Entrez ID		1653	3190
HPRD ID		03158	02834
Ensembl ID		ENSG00000079785	ENSG00000165119
Uniprot IDs		A3RJH1 Q92499	B4DFF1 B4DUQ1 P61978 Q6IBN1
PDB IDs			1J5K 1KHM 1ZZI 1ZZJ 1ZZK
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process Nervous System Development MRNA Polyadenylation Positive Regulation Of Cell Cycle Process RNA Polyadenylation Brain Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Head Development Positive Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Neuron Apoptotic Process Signal Transduction Central Nervous System Development Neuron Death Response To Abiotic Stimulus Signaling MRNA Processing DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Communication MRNA 3'-end Processing Response To Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Acetaldehyde Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process RNA 3'-end Processing System Development Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Positive Regulation Of Schwann Cell Differentiation RNA Processing Cellular Response To Stimulus Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Collateral Sprouting In Absence Of Injury Regulation Of Schwann Cell Differentiation Nucleobase-containing Compound Metabolic Process Cell Activation Multicellular Organismal Development Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Response To Cobalamin Anatomical Structure Development Pre-B Cell Allelic Exclusion Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway	RNA Processing MRNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Posttranscriptional Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Immune Response Positive Regulation Of Metabolic Process MRNA Stabilization Innate Immune Response Regulation Of Nitrogen Compound Metabolic Process Regulation Of MRNA Processing Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Metabolic Process Regulation Of Translation Negative Regulation Of Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Immune System Process Positive Regulation Of Gene Expression Regulation Of Immune System Process Defense Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		apply asp clcn7 complementation complementing disequilibrium erb ercc1 erythroblastic exo1 exonuclease gwas helicase inconsistent nominal perfect phosphoprotein prerequisite reexamined replicate replicating rs2844484 rs2857602 spp1 stringent swedish tmc6 tmc8 underscore	associates boosted consequently cpg dnmt1 facilitated h3k9 h3k9me3 heterochromatin impairs insight instead intergenic lincrna link lncrnas methyltransferase noncoding notably p21 pluripotency prevents profiling promoters reprogramming rnas setdb1 somatic sustaining
Tagcloud (Difference) ?		apply asp clcn7 complementation complementing disequilibrium erb ercc1 erythroblastic exo1 exonuclease gwas helicase inconsistent nominal perfect phosphoprotein prerequisite reexamined replicate replicating rs2844484 rs2857602 spp1 stringent swedish tmc6 tmc8 underscore	associates boosted consequently cpg dnmt1 facilitated h3k9 h3k9me3 heterochromatin impairs insight instead intergenic lincrna link lncrnas methyltransferase noncoding notably p21 pluripotency prevents profiling promoters reprogramming rnas setdb1 somatic sustaining
Tagcloud (Intersection) ?