DLEU1 and EEF1A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLEU1	EEF1A1
Description		deleted in lymphocytic leukemia 1	eukaryotic translation elongation factor 1 alpha 1
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Ribosome Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Cytosolic Ribosome Cortical Actin Cytoskeleton Ruffle Membrane Secretory Granule Lumen Extracellular Exosome Cytoplasmic Side Of Lysosomal Membrane Ficolin-1-rich Granule Lumen
	Molecular Function		TRNA Binding Nucleotide Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Kinase Activator Activity Kinase Binding Protein Kinase Binding Molecular Adaptor Activity
	Biological Process		Translation Translational Elongation Host-mediated Activation Of Viral Genome Replication Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Chaperone-mediated Autophagy
Pathways			Eukaryotic Translation Elongation Eukaryotic Translation Elongation Peptide chain elongation HSF1 activation Neutrophil degranulation Protein methylation Chaperone Mediated Autophagy SARS-CoV-1 modulates host translation machinery
Drugs			Zinc Guanosine-5'-Diphosphate Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		A body shape index ( 34021172) Adiponectin levels ( 26299439) Adiponectin levels (BMI-adjusted) ( 26299439) Aluminium levels ( 26025379) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163) Circulating odd-numbered chain saturated fatty acid levels (C19:0) ( 29738550) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) FEV1 ( 30804560) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196 33713608 31562340 31217584) Hematocrit ( 29403010 32888494) Hemoglobin ( 29403010 32888494) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Lipoprotein (a) levels ( 30108283) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 27386562 21833088 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Plasma anti-thyroid peroxidase levels ( 29678681) Platelet distribution width ( 32888494) Primary biliary cholangitis ( 26394269) Prostate-specific antigen levels ( 28139693) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tumor necrosis factor alpha levels ( 31217265) Type 2 diabetes ( 30297969 30054458 32499647) Urinary albumin-to-creatinine ratio ( 31630189) Urinary magnesium excretion ( 31993563) Waist-hip index ( 34021172) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ABCD4 ABCF3 ARL8B CCDC90B CEP126 COPS6 EEF1A1 EEF1G GDF9 GOPC KAT5 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A	144 interacting genes: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 AQP2 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCL18 CDC25A CDKN1A CEBPA CKS2 CLIC6 COX17 CRADD CRCT1 CREBBP CSRP2 CTIF DARS1 DCTN1 DIABLO DLEU1 DNMT1 DNMT3A DUSP7 DYNLL1 DYSF EIF3F EP300 EXOSC4 FAS GADD45A GADD45G HOXA1 HSPB2 HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP OGT ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP PTPRF RAB27A RAP2A RFC5 RGS12 RND1 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB5 SERPINB9 SF3B4 SFN SHBG SMAD2 SMAD4 SMN1 SPATS2L SPP1 SSR1 STAT6 STMN2 SULT1E1 SUMO2 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSC2 TSPY1 TSPYL2 TTLL12 TTR TXNIP UBQLN4 USP40 VHL WARS1 WEE2-AS1 XPO5 XRN2 YJU2B YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1
Entrez ID		10301	1915
HPRD ID		16150	00559
Ensembl ID		ENSG00000176124	ENSG00000156508
Uniprot IDs			P68104 Q6IPS9
PDB IDs			3C5J 6ZMO 8G60 8G6J
Enriched GO Terms of Interacting Partners?			Cytoplasm Apoptotic Process Cell Death Programmed Cell Death Regulation Of Programmed Cell Death Cytosol Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Negative Regulation Of Metabolic Process Regulation Of Apoptotic Process Nucleic Acid Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway BBSome Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Protein-containing Complex Nucleus Macromolecule Biosynthetic Process Melanosome Transport Tau Protein Binding Regulation Of Developmental Process RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Pigment Granule Transport Negative Regulation Of Protein Phosphorylation Cellular Response To Stress Melanosome Localization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Macromolecule Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pigment Granule Localization Mitochondrial Intermembrane Space Nucleoplasm Protein Binding Negative Regulation Of Catalytic Activity Histone H3K27 Acetyltransferase Activity Negative Regulation Of Phosphate Metabolic Process TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Phosphorus Metabolic Process
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