DLEU1 and UBR1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		DLEU1	UBR1
Gene Name		deleted in lymphocytic leukemia 1 (non-protein coding)	ubiquitin protein ligase E3 component n-recognin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Ubiquitin Ligase Complex Proteasome Complex Cytosol
	Molecular Function		Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Leucine Binding
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		19 interactors: ABCD4 ABCF3 ARL8B CCDC90B COPS6 EEF1A1 EEF1G GDF9 KAT5 KIAA1377 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A	26 interactors: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBC UBE2A UBE2B
Entrez ID		10301	197131
HPRD ID		16150	09342
Ensembl ID		ENSG00000176124	ENSG00000159459
Uniprot IDs			Q8IWV7
PDB IDs			3NY1
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction Resulting In Transcription Signal Transduction By P53 Class Mediator Negative Regulation Of Fibroblast Proliferation Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process Negative Regulation Of Macromitophagy Cellular Response To Leucine Oocyte Growth Oligodendrocyte Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Water-soluble Vitamin Metabolic Process Mitotic Cell Cycle Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic DNA Damage Checkpoint Negative Regulation Of Helicase Activity Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Cell Cycle Cellular Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Protein Tetramerization L-serine Catabolic Process Regulation Of Progesterone Secretion Vitamin Metabolic Process Carnitine Biosynthetic Process Positive Regulation Of Protein Modification Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spindle Organization Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Metabolic Process Notch Signaling Pathway Transcription, DNA-templated	Response To Stimulus Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Cellular Localization Cellular Response To Stimulus Regulation Of Kinase Activity Establishment Of Localization In Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Cell Cycle Signaling Intracellular Signal Transduction Regulation Of Catalytic Activity Cellular Response To Organic Substance Cell Communication Regulation Of Cellular Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stress Response To Radiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Process Regulation Of Cell Death Signal Transduction Regulation Of ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Immune System Process Histone H2A Ubiquitination Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity
Tagcloud ?		10q23 11q22 12p13 13q14 17p13 21q22 2p23 5q32 6q21 7p12 7q21 8q24 9p13 9p21 9p24 acgh dleu2 ebf1 ikzf1 imbalances interrogate mir145a mir146a mir15a mlpa pax5 probemix uncovering undetected	26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Difference) ?		10q23 11q22 12p13 13q14 17p13 21q22 2p23 5q32 6q21 7p12 7q21 8q24 9p13 9p21 9p24 acgh dleu2 ebf1 ikzf1 imbalances interrogate mir145a mir146a mir15a mlpa pax5 probemix uncovering undetected	26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated
Tagcloud (Intersection) ?