FRK

Description		fyn related Src family tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Symbiont-mediated Suppression Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Innate Immune Response
Pathways		Neutrophil degranulation Regulation of PTEN stability and activity
Drugs		Dasatinib Regorafenib Fostamatinib Zanubrutinib
Diseases
GWAS		Age-related macular degeneration ( 21665990) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 28724990) Aspartate aminotransferase levels ( 34315874 33547301) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) High density lipoprotein cholesterol levels ( 33339817) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Low density lipoprotein cholesterol levels ( 32154731) Photic sneeze reflex ( 27182965) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 28334899) Urate levels ( 23263486)
Novel Interacting Genes		1 novel interacting genes: PRDM1
Interacting Genes		6 interacting genes: BNIP2 EGFR KHDRBS1 RB1 SF3B4 SKAP2
Entrez ID		2444
HPRD ID		05954
Ensembl ID		ENSG00000111816
Uniprot IDs		P42685
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelial Cell Proliferation Embryonic Placenta Development Neuron Differentiation Sebum Secreting Cell Proliferation Regulation Of Cell Population Proliferation Embryonic Organ Development Cell Population Proliferation Regulation Of NK T Cell Differentiation Regulation Of Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Striated Muscle Cell Differentiation Regulation Of Programmed Cell Death Muscle Cell Differentiation Regulation Of Apoptotic Process Regulation Of Protein Kinase C Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Kinase Binding Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Epidermal Growth Factor Binding Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Cell Morphogenesis Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Multivesicular Body, Internal Vesicle Lumen Negative Regulation Of Myofibroblast Differentiation Mitotic Cell Cycle Phase Transition Sister Chromatid Biorientation Cell Cycle G1/S Phase Transition Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Glial Cell Apoptotic Process Rb-E2F Complex Regulation Of Centromere Complex Assembly Chromatin Lock Complex Cell Cycle Phase Transition Positive Regulation Of Collagen Fibril Organization Splicing Factor Binding Positive Regulation Of RNA Export From Nucleus Grb2-Sos Complex Enucleate Erythrocyte Differentiation ERBB2-EGFR Signaling Pathway Cyclin/CDK Positive Transcription Elongation Factor Complex Retinal Bipolar Neuron Differentiation Maternal Placenta Development Developmental Process Involved In Reproduction
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