FRK and BNIP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FRK	BNIP2
Gene Name		fyn-related Src family tyrosine kinase	BCL2/adenovirus E1B 19kDa interacting protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Nuclear Envelope Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	GTPase Activator Activity Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Cell Migration Actin Cytoskeleton Organization Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response	Apoptotic Process Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Muscle Cell Differentiation
Pathways			CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21665990) Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Urate levels ( 23263486)
Protein-Protein Interactions		4 interactors: BNIP2 KHDRBS1 RB1 SF3B4	13 interactors: ARHGAP1 ARHGAP8 BCL2 BNIPL CDC42 CREB3 FATE1 FGFR1 FRK KLC1 MYO5B NCBP1 UPK1B
Entrez ID		2444	663
HPRD ID		05954	04481
Ensembl ID			ENSG00000140299
Uniprot IDs		P42685	J3KN59 Q12982
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Cell Cycle Arrest Positive Regulation Of RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Positive Regulation Of Metabolic Process Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Striated Muscle Cell Differentiation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Muscle Cell Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore MRNA Processing Positive Regulation Of Macrophage Differentiation Microtubule Cytoskeleton Organization Regulation Of RNA Export From Nucleus Negative Regulation Of Cell Cycle Positive Regulation Of Translational Initiation Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation Positive Regulation Of Chromosome Segregation Muscle Structure Development Regulation Of Sister Chromatid Cohesion MRNA Metabolic Process Hepatocyte Apoptotic Process RNA Processing Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA Splicing, Via Spliceosome Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Protein Localization To Chromosome Neuron Maturation Sister Chromatid Cohesion Metaphase Plate Congression Negative Regulation Of Smoothened Signaling Pathway Mitotic Cell Cycle Positive Regulation Of RNA Splicing Regulation Of Signal Transduction Microtubule-based Process Androgen Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Establishment Of Chromosome Localization	Regulation Of Protein Heterodimerization Activity Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Gland Morphogenesis Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Hair Follicle Morphogenesis Regulation Of Growth Epidermis Morphogenesis Salivary Gland Morphogenesis Positive Regulation Of Signal Transduction Salivary Gland Development Epidermis Development Skin Morphogenesis Neural Nucleus Development Cell Fate Commitment Exocrine System Development Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Negative Regulation Of Cellular PH Reduction Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cellular Metabolic Process Midbrain Development Positive Regulation Of Muscle Cell Differentiation Adherens Junction Organization Regulation Of Cell Cycle Hair Follicle Development Stress Granule Disassembly Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Lateral Mesodermal Cell Fate Specification Release From Viral Latency Hair Cycle Process Renal System Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-serine Phosphorylation
Tagcloud ?		accompanied accumulation alters arrest consequent disclosed distinctive e2f1 fyn g1 glioma hyperphosphorylated importantly inhibiting investigation member noteworthy nucleus prb proliferating proliferative promoted proper protective retinoblastoma sirna src suppressing suppressive	activator antiapoptotic attenuated bcl blocks cleavage cytotoxicity deacetylase imply inhibits intensified mediate mpp nad neuroprotective parp participates phenylpyridinium possibly resveratrol sh shrna sirna sirt1 sirtuin sy5y transfected transfection xl
Tagcloud (Difference) ?		accompanied accumulation alters arrest consequent disclosed distinctive e2f1 fyn g1 glioma hyperphosphorylated importantly inhibiting investigation member noteworthy nucleus prb proliferating proliferative promoted proper protective retinoblastoma src suppressing suppressive	activator antiapoptotic attenuated bcl blocks cleavage cytotoxicity deacetylase imply inhibits intensified mediate mpp nad neuroprotective parp participates phenylpyridinium possibly resveratrol sh shrna sirt1 sirtuin sy5y transfected transfection xl
Tagcloud (Intersection) ?		sirna