NOTCH3 and SNX19

Number of citations of the paper that reports this interaction (PubMedID 25356737)
22

Data Source:
BioGRID (pull down)

		NOTCH3	SNX19
Description		notch receptor 3	sorting nexin 19
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane Receptor Complex	Cytoplasm Endosome Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Notch Signaling Pathway Axon Guidance Neuroblast Differentiation Cell Differentiation Neuron Differentiation Forebrain Development Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Regulation Of Developmental Process Glomerular Capillary Formation Positive Regulation Of MiRNA Transcription	Chondrocyte Differentiation Exocytosis Protein Transport Insulin Secretion Establishment Of Localization In Cell Dense Core Granule Maturation
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)	Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Pulse pressure ( 27841878 30224653 30578418) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260)
Interacting Genes		53 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8	2 interacting genes: NOTCH3 PTPRN
Entrez ID		4854	399979
HPRD ID		02607	18621
Ensembl ID		ENSG00000074181	ENSG00000120451
Uniprot IDs		Q9UM47	B7ZAU9 E9PJV7 E9PLV3 Q92543
PDB IDs		4ZLP 5CZV 5CZX 6WQU 6XSW 8OS0
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Notch Binding Tissue Morphogenesis Regulation Of Timing Of Cell Differentiation Regulation Of Notch Signaling Pathway Regulation Of Development, Heterochronic MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Tube Morphogenesis Positive Regulation Of Developmental Process Endothelial Cell Fate Specification Morphogenesis Of An Epithelium Cell Surface Receptor Signaling Pathway Loop Of Henle Development Calcium Ion Binding Neuron Differentiation Myoblast Differentiation Negative Regulation Of Viral Life Cycle Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Inhibition Of Neuroepithelial Cell Differentiation Gamma-secretase Complex Positive Regulation Of Signal Transduction Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Lymphocyte Migration Into Lymphoid Organs Notch Receptor Processing Transcription Coactivator Activity Negative Regulation Of Notch Signaling Pathway Epithelial Tube Morphogenesis Positive Regulation Of Kidney Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Amyloid-beta Formation Somitogenesis Anatomical Structure Morphogenesis Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Stem Cell Population Maintenance Endothelial Tube Morphogenesis Segmentation Maintenance Of Cell Number Positive Regulation Of Cellular Component Organization Nephron Development Inner Ear Development	Response To Anesthetic Ripoptosome Death Effector Domain Binding Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Death-inducing Signaling Complex Angiogenesis CD95 Death-inducing Signaling Complex Glomerular Capillary Formation Neuroblast Differentiation Dense Core Granule Maturation Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Pyroptotic Inflammatory Response Self Proteolysis Response To Cobalt Ion TRAIL-activated Apoptotic Signaling Pathway Luteinization Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Macrophage Differentiation Death Receptor Binding Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Transcription Factor Binding Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Macrophage Differentiation Execution Phase Of Apoptosis Ubiquitin-like Protein Ligase Binding Spectrin Binding
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