NOTCH3 and SCGB3A1

Number of citations of the paper that reports this interaction (PubMedID 25356737)
22

Data Source:
BioGRID (pull down)

		NOTCH3	SCGB3A1
Description		notch receptor 3	secretoglobin family 3A member 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Cytokine Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Notch Signaling Pathway Axon Guidance Neuroblast Differentiation Cell Differentiation Neuron Differentiation Forebrain Development Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Regulation Of Developmental Process Glomerular Capillary Formation Positive Regulation Of MiRNA Transcription	Signal Transduction Negative Regulation Of Cell Growth Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Fusion
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)	Blood protein levels ( 30072576) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		53 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8	10 interacting genes: AURKA BAG4 FBXW7 FGFR4 MARCO NOTCH3 RHBDD2 TGFB1 TSG101 XRCC3
Entrez ID		4854	92304
HPRD ID		02607	05932
Ensembl ID		ENSG00000074181	ENSG00000161055
Uniprot IDs		Q9UM47	Q96QR1
PDB IDs		4ZLP 5CZV 5CZX 6WQU 6XSW 8OS0
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Notch Binding Tissue Morphogenesis Regulation Of Timing Of Cell Differentiation Regulation Of Notch Signaling Pathway Regulation Of Development, Heterochronic MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Tube Morphogenesis Positive Regulation Of Developmental Process Endothelial Cell Fate Specification Morphogenesis Of An Epithelium Cell Surface Receptor Signaling Pathway Loop Of Henle Development Calcium Ion Binding Neuron Differentiation Myoblast Differentiation Negative Regulation Of Viral Life Cycle Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Inhibition Of Neuroepithelial Cell Differentiation Gamma-secretase Complex Positive Regulation Of Signal Transduction Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Lymphocyte Migration Into Lymphoid Organs Notch Receptor Processing Transcription Coactivator Activity Negative Regulation Of Notch Signaling Pathway Epithelial Tube Morphogenesis Positive Regulation Of Kidney Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Amyloid-beta Formation Somitogenesis Anatomical Structure Morphogenesis Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Stem Cell Population Maintenance Endothelial Tube Morphogenesis Segmentation Maintenance Of Cell Number Positive Regulation Of Cellular Component Organization Nephron Development Inner Ear Development	Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Fibroblast Migration Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Extracellular Matrix Disassembly Positive Regulation Of MAPK Cascade Lipid Homeostasis Regulation Of Signaling Regulation Of Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Liver Regeneration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Macromolecule Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Establishment Of Protein Localization Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Fibroblast Migration Protein Catabolic Process Regulation Of Organelle Organization Proteolysis Regulation Of Protein Targeting To Mitochondrion Regulation Of MAPK Cascade Positive Regulation Of Cell Cycle Process Positive Regulation Of MiRNA Transcription Regulation Of Cell Cycle Process Regulation Of Centrosome Cycle Animal Organ Regeneration Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Vasculature Development Cellular Response To Acetaldehyde Negative Regulation Of MRNA Modification Positive Regulation Of MiRNA Metabolic Process Regulation Of Extracellular Matrix Organization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Cycle
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