NOTCH3 and MAML2

Number of citations of the paper that reports this interaction (PubMedID 12370315)
58

Data Source:
HPRD (in vivo)

		NOTCH3	MAML2
Description		notch receptor 3	mastermind like transcriptional coactivator 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane Receptor Complex	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Notch Signaling Pathway Axon Guidance Neuroblast Differentiation Cell Differentiation Neuron Differentiation Forebrain Development Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Regulation Of Developmental Process Glomerular Capillary Formation Positive Regulation Of MiRNA Transcription	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 23322567) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 23456168) Hematocrit ( 32888494) Hemoglobin ( 32888494) Influenza A (H1N1) severity ( 26379185) Keratoconus ( 31855235) Methadone dose in opioid dependence ( 28115739) Non-glioblastoma glioma ( 28346443) Pelvic organ prolapse ( 26545240) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Response to treatment for acute lymphoblastic leukemia ( 19176441) Ulcerative colitis ( 23128233 28067908) Waist-to-hip circumference ratio (alcohol intake interaction) ( 23192594)
Interacting Genes		53 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8	8 interacting genes: CREBBP CTBP1 DIABLO NEDD4 NOTCH1 NOTCH2 NOTCH3 NOTCH4
Entrez ID		4854	84441
HPRD ID		02607	09608
Ensembl ID		ENSG00000074181	ENSG00000184384
Uniprot IDs		Q9UM47	Q8IZL2
PDB IDs		4ZLP 5CZV 5CZX 6WQU 6XSW 8OS0
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Notch Binding Tissue Morphogenesis Regulation Of Timing Of Cell Differentiation Regulation Of Notch Signaling Pathway Regulation Of Development, Heterochronic MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Tube Morphogenesis Positive Regulation Of Developmental Process Endothelial Cell Fate Specification Morphogenesis Of An Epithelium Cell Surface Receptor Signaling Pathway Loop Of Henle Development Calcium Ion Binding Neuron Differentiation Myoblast Differentiation Negative Regulation Of Viral Life Cycle Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Inhibition Of Neuroepithelial Cell Differentiation Gamma-secretase Complex Positive Regulation Of Signal Transduction Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Lymphocyte Migration Into Lymphoid Organs Notch Receptor Processing Transcription Coactivator Activity Negative Regulation Of Notch Signaling Pathway Epithelial Tube Morphogenesis Positive Regulation Of Kidney Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Amyloid-beta Formation Somitogenesis Anatomical Structure Morphogenesis Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Stem Cell Population Maintenance Endothelial Tube Morphogenesis Segmentation Maintenance Of Cell Number Positive Regulation Of Cellular Component Organization Nephron Development Inner Ear Development	Notch Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Coactivator Activity Negative Regulation Of RNA Biosynthetic Process Tube Morphogenesis Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Cell Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Luteolysis Atrioventricular Node Development Glomerular Capillary Formation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription Of Notch Receptor Target Signaling Receptor Activity Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Adhesion Molecule Production Anatomical Structure Morphogenesis Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Macromolecule Metabolic Process Blood Vessel Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Endocardial Cushion Development Left/right Axis Specification Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of RNA Metabolic Process Morphogenesis Of An Epithelial Sheet Neuron Projection Development Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nephron Tubule Development Regulation Of RNA Biosynthetic Process Notch Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Renal Tubule Development Receptor Complex
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