NOTCH3 and JAG1

Number of citations of the paper that reports this interaction (PubMedID 14714274)
35

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		NOTCH3	JAG1
Description		notch receptor 3	jagged canonical Notch ligand 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Apical Part Of Cell
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Growth Factor Activity Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Notch Signaling Pathway Axon Guidance Neuroblast Differentiation Cell Differentiation Neuron Differentiation Forebrain Development Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Regulation Of Developmental Process Glomerular Capillary Formation Positive Regulation Of MiRNA Transcription	Angiogenesis Cell Fate Determination Negative Regulation Of Cell-matrix Adhesion Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet Inhibition Of Neuroepithelial Cell Differentiation T Cell Mediated Immunity Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Cell Communication Notch Signaling Pathway Nervous System Development Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell-cell Adhesion Hemopoiesis Neuron Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Auditory Receptor Cell Differentiation Camera-type Eye Development Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Neuroendocrine Cell Differentiation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Endocardial Cushion Cell Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Nephron Development Podocyte Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus RUNX3 regulates NOTCH signaling RAC1 GTPase cycle RAC3 GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Nephron development
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)	Tetralogy of Fallot Alagille syndrome
GWAS		Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)	Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Bone mineral density ( 20096396) Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 21909115 27618447 27618452 26390057 27841878 25249183 28135244 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Eosinophil count ( 32888494) Frontotemporal dementia (age at onset) ( 29724592) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density ( 22504420 29499414) Lymphocyte count ( 32888494) Migraine ( 27322543) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Red blood cell count ( 32888494) Systolic blood pressure ( 28739976 28135244 27841878 25249183 27618452 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 28828242) Urate levels ( 31578528) Urinary bladder cancer ( 24861552)
Interacting Genes		53 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8	9 interacting genes: AFDN MFNG MIB1 MTDH NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1
Entrez ID		4854	182
HPRD ID		02607	03562
Ensembl ID		ENSG00000074181	ENSG00000101384
Uniprot IDs		Q9UM47	P78504 Q99740
PDB IDs		4ZLP 5CZV 5CZX 6WQU 6XSW 8OS0	2KB9 2VJ2 4CBZ 4CC0 4CC1 4XI7 5BO1
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Notch Binding Tissue Morphogenesis Regulation Of Timing Of Cell Differentiation Regulation Of Notch Signaling Pathway Regulation Of Development, Heterochronic MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Tube Morphogenesis Positive Regulation Of Developmental Process Endothelial Cell Fate Specification Morphogenesis Of An Epithelium Cell Surface Receptor Signaling Pathway Loop Of Henle Development Calcium Ion Binding Neuron Differentiation Myoblast Differentiation Negative Regulation Of Viral Life Cycle Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Inhibition Of Neuroepithelial Cell Differentiation Gamma-secretase Complex Positive Regulation Of Signal Transduction Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Lymphocyte Migration Into Lymphoid Organs Notch Receptor Processing Transcription Coactivator Activity Negative Regulation Of Notch Signaling Pathway Epithelial Tube Morphogenesis Positive Regulation Of Kidney Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Amyloid-beta Formation Somitogenesis Anatomical Structure Morphogenesis Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Stem Cell Population Maintenance Endothelial Tube Morphogenesis Segmentation Maintenance Of Cell Number Positive Regulation Of Cellular Component Organization Nephron Development Inner Ear Development	Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Angiogenesis Cellular Response To Tumor Cell Pattern Specification Process Negative Regulation Of Endothelial Cell Chemotaxis Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Neuron Differentiation Marginal Zone B Cell Differentiation Regulation Of Notch Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Left/right Axis Specification Epithelial Tube Morphogenesis Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Renal Tubule Development Anterior/posterior Pattern Specification Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mature B Cell Differentiation Involved In Immune Response Regulation Of Neuron Differentiation NF-kappaB Binding Mature B Cell Differentiation Receptor Complex Inflammatory Response To Antigenic Stimulus Sprouting Angiogenesis Positive Regulation Of BMP Signaling Pathway Neuron Fate Commitment Neuron Projection Guidance Axon Guidance Positive Regulation Of Notch Signaling Pathway Calcium Ion Binding Golgi Membrane Regulation Of Smooth Muscle Cell Differentiation In Utero Embryonic Development Cell Surface Receptor Signaling Pathway Regulation Of Ras Protein Signal Transduction Somitogenesis Chordate Embryonic Development Cell Surface Negative Regulation Of Chemotaxis Signal Transduction
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