NOTCH3 and PPIA

Number of citations of the paper that reports this interaction (PubMedID 25356737)
22

Data Source:
BioGRID (pull down)

		NOTCH3	PPIA
Description		notch receptor 3	peptidylprolyl isomerase A
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Vesicle Protein-containing Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Integrin Binding Protein Binding Cyclosporin A Binding Isomerase Activity Virion Binding Unfolded Protein Binding Heparan Sulfate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Notch Signaling Pathway Axon Guidance Neuroblast Differentiation Cell Differentiation Neuron Differentiation Forebrain Development Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Regulation Of Developmental Process Glomerular Capillary Formation Positive Regulation Of MiRNA Transcription	Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Folding Negative Regulation Of Protein Kinase Activity Apoptotic Process Viral Release From Host Cell Platelet Activation Neuron Differentiation Neutrophil Chemotaxis Leukocyte Chemotaxis Activation Of Protein Kinase B Activity Negative Regulation Of Stress-activated MAPK Cascade Lipid Droplet Organization Cellular Response To Oxidative Stress Endothelial Cell Activation Positive Regulation Of MAPK Cascade Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Adhesion Molecule Production Negative Regulation Of Protein K48-linked Ubiquitination Platelet Aggregation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Life Cycle Regulation Of Apoptotic Signaling Pathway
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3	Platelet degranulation Uncoating of the HIV Virion Budding and maturation of HIV virion Integration of provirus Early Phase of HIV Life Cycle Minus-strand DNA synthesis Plus-strand DNA synthesis Binding and entry of HIV virion Assembly Of The HIV Virion APOBEC3G mediated resistance to HIV-1 infection Calcineurin activates NFAT Basigin interactions Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation SARS-CoV-1 activates/modulates innate immune responses
Drugs			Cyclosporine Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate Sanglifehrin A Copper Artenimol
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)	Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		53 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8	30 interacting genes: APP BSG CD99 ERCC6 ERRFI1 G3BP1 GRSF1 ITK JAK2 LIG4 LNX1 N4BP2L2 NOTCH3 PAXIP1 PDE4B PRLR PRR13 PRSS23 PTPRN RB1 S100A8 SRPK1 SRPK2 SUPT5H TCF4 TERT UBE3A USP4 WBP4 YY1
Entrez ID		4854	5478
HPRD ID		02607	00457
Ensembl ID		ENSG00000074181	ENSG00000196262
Uniprot IDs		Q9UM47	P62937 V9HWF5
PDB IDs		4ZLP 5CZV 5CZX 6WQU 6XSW 8OS0	1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2MS4 2MZU 2N0T 2RMA 2RMB 2X25 2X2A 2X2C 2X2D 2XGY 3CYH 3CYS 3K0M 3K0N 3K0O 3K0P 3K0Q 3K0R 3ODI 3ODL 3RDD 4CYH 4IPZ 4N1M 4N1N 4N1O 4N1P 4N1Q 4N1R 4N1S 4YUG 4YUH 4YUI 4YUJ 4YUK 4YUL 4YUM 4YUN 4YUO 4YUP 5CYH 5F66 5FJB 5KUL 5KUN 5KUO 5KUQ 5KUR 5KUS 5KUU 5KUV 5KUW 5KUZ 5KV0 5KV1 5KV2 5KV3 5KV4 5KV5 5KV6 5KV7 5LUD 5NOQ 5NOR 5NOS 5NOT 5NOU 5NOV 5NOW 5NOX 5NOY 5NOZ 5T9U 5T9W 5T9Z 5TA2 5TA4 5WC7 6BTA 6GJI 6GJJ 6GJL 6GJM 6GJN 6GJP 6GJR 6GJY 6GS6 6I42 6U5C 6U5D 6U5E 6U5G 6X3R 6X3Y 6X4M 6X4N 6X4O 6X4P 6X4Q 6Y9V 6Y9W 6Y9X 6Y9Y 6Y9Z 6ZDJ 7ABT 7N9X 7PCJ 7QBW 7TA8 7UPN 7UXJ 7UXM 7UXN 8G9P 8G9Q 8HZ8 8TBF 8TBG 8TBH 8TBI 8TBJ 8TBK 8TBL 8TBM 8TBN 9AX6 9BFW 9BFY 9BFZ 9BG1 9BHO 9BHP 9BHQ 9BI1 9BI2 9GHY
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Notch Binding Tissue Morphogenesis Regulation Of Timing Of Cell Differentiation Regulation Of Notch Signaling Pathway Regulation Of Development, Heterochronic MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Tube Morphogenesis Positive Regulation Of Developmental Process Endothelial Cell Fate Specification Morphogenesis Of An Epithelium Cell Surface Receptor Signaling Pathway Loop Of Henle Development Calcium Ion Binding Neuron Differentiation Myoblast Differentiation Negative Regulation Of Viral Life Cycle Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Inhibition Of Neuroepithelial Cell Differentiation Gamma-secretase Complex Positive Regulation Of Signal Transduction Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Lymphocyte Migration Into Lymphoid Organs Notch Receptor Processing Transcription Coactivator Activity Negative Regulation Of Notch Signaling Pathway Epithelial Tube Morphogenesis Positive Regulation Of Kidney Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Amyloid-beta Formation Somitogenesis Anatomical Structure Morphogenesis Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Stem Cell Population Maintenance Endothelial Tube Morphogenesis Segmentation Maintenance Of Cell Number Positive Regulation Of Cellular Component Organization Nephron Development Inner Ear Development	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Developmental Process Nucleus Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Endosome Lumen Regulation Of MiRNA Transcription Regulation Of Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Activation Of Janus Kinase Activity Intracellular Signal Transduction Regulation Of Cell Differentiation Immune System Process Regulation Of RNA Metabolic Process Regulation Of Cytokine Production Regulation Of Primary Metabolic Process Regulation Of Neuron Apoptotic Process Chromatin Organization Response To Stress Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Signaling Receptor Activator Activity Embryo Implantation Nucleic Acid Metabolic Process Immunoglobulin V(D)J Recombination Chromatin Remodeling Neutrophil Chemotaxis Hormone-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Prostate Gland Growth Cellular Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Development Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Mammary Gland Epithelium Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Viral Process
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