KAT7 and POLB

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		KAT7	POLB
Gene Name		K(lysine) acetyltransferase 7	polymerase (DNA directed), beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Microtubule Spindle Microtubule
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Microtubule Binding Lyase Activity Enzyme Binding Metal Ion Binding
	Biological Process	DNA Replication Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation	DNA-dependent DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Pyrimidine Dimer Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ethanol Neuron Apoptotic Process DNA Biosynthetic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs			Cytarabine 2\'-Deoxyadenosine 5\'-Triphosphate (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
Diseases
GWAS
Protein-Protein Interactions		43 interactors: APP AR ATN1 BARD1 CAAP1 CALCOCO2 CBX8 CDC6 CDK11B CEP70 CSNK1E DDX11 DVL3 DYNC1I1 GMNN HAP1 HIST1H3A HIST1H4A HIST2H2AC HOOK2 ING4 JADE1 KATNBL1 KCTD13 KIAA1377 LRIF1 MCM2 NINL ORC1 ORC2 PACSIN1 POLB PPID RGL2 RPS10 SAT1 SEPT5 SNAPIN TP53 VIM WDR33 ZBTB8A ZNF165	17 interactors: APEX1 EP300 HUWE1 KAT7 NEIL1 PARP1 PCNA PNKP PRKCA RAD1 SRPK2 STUB1 TAF1D TLE1 TPP2 WRN XRCC1
Entrez ID		11143	5423
HPRD ID		07135	07517
Ensembl ID		ENSG00000136504	ENSG00000070501
Uniprot IDs		O95251	B7Z1W5 P06746
PDB IDs			1BPX 1BPY 1BPZ 1MQ2 1MQ3 1TV9 1TVA 1ZJM 1ZJN 1ZQA 1ZQB 1ZQC 1ZQD 1ZQE 1ZQF 1ZQG 1ZQH 1ZQI 1ZQJ 1ZQK 1ZQL 1ZQM 1ZQN 1ZQO 1ZQP 1ZQQ 1ZQR 1ZQS 1ZQT 2FMP 2FMQ 2FMS 2I9G 2ISO 2ISP 2P66 2PXI 3C2K 3C2L 3C2M 3GDX 3ISB 3ISC 3ISD 3JPN 3JPO 3JPP 3JPQ 3JPR 3JPS 3JPT 3LK9 3MBY 3OGU 3RH4 3RH5 3RH6 3RJE 3RJF 3RJG 3RJH 3RJI 3RJJ 3RJK 3TFR 3TFS 4DO9 4DOA 4DOB 4DOC 4F5N 4F5O 4F5P 4F5Q 4F5R 4GXI 4GXJ 4GXK 4JWM 4JWN 4KLD 4KLE 4KLF 4KLG 4KLH 4KLI 4KLJ 4KLL 4KLM 4KLO 4KLQ 4KLS 4KLT 4KLU 4LVS 7ICE 7ICF 7ICG 7ICH 7ICI 7ICJ 7ICK 7ICL 7ICM 7ICN 7ICO 7ICP 7ICQ 7ICR 7ICS 7ICT 7ICU 7ICV 8ICA 8ICB 8ICC 8ICE 8ICF 8ICG 8ICH 8ICI 8ICJ 8ICK 8ICL 8ICM 8ICN 8ICO 8ICP 8ICQ 8ICR 8ICS 8ICT 8ICU 8ICV 8ICW 8ICX 8ICY 8ICZ 9ICA 9ICB 9ICC 9ICE 9ICF 9ICG 9ICH 9ICI 9ICJ 9ICK 9ICL 9ICM 9ICN 9ICO 9ICP 9ICQ 9ICR 9ICS 9ICT 9ICU 9ICV 9ICW 9ICX 9ICY
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA-dependent DNA Replication Negative Regulation Of Biosynthetic Process Neuron Apoptotic Process Regulation Of RNA Metabolic Process Apoptotic Process Neuron Death Programmed Cell Death Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Replication Initiation Regulation Of Cell Cycle Establishment Of Vesicle Localization Vesicle Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Viral Process Chromosome Organization Regulation Of Cell Cycle Phase Transition Cellular Macromolecule Biosynthetic Process Cellular Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of DNA Replication Negative Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Microtubule-based Transport	Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Nitrogen Compound Metabolic Process DNA Replication Chromosome Organization Telomere Maintenance Nucleotide-excision Repair Cellular Metabolic Process DNA-dependent DNA Replication Regulation Of Growth Rate Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process Cellular Response To Stimulus Response To Oxidative Stress DNA Damage Response, Detection Of DNA Damage Cellular Macromolecule Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Response To Stimulus Telomere Maintenance Via Semi-conservative Replication Metabolic Process Organelle Organization Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Response To Radiation Histone Modification Double-strand Break Repair Positive Regulation Of Metabolic Process Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Gene Expression DNA Strand Elongation Negative Regulation Of Biosynthetic Process Aromatic Compound Catabolic Process Protein Polyubiquitination Telomere Maintenance Via Telomere Lengthening Response To Radiation DNA Catabolic Process, Exonucleolytic Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Transcription-coupled Nucleotide-excision Repair
Tagcloud ?		acetyltransferase acetyltransferases analogs anticancer assayed campaign cascades deacetylases discover docked extremely gcn5 ic50 kat3b kat5 kat6b l002 mb mda methyltransferases mumol nci nsc764414 paralog potently therapeutics throughput tnbc xenografts	accessible applicable cancerous chosen constitute crc csnk1e ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Difference) ?		acetyltransferase acetyltransferases analogs anticancer assayed campaign cascades deacetylases discover docked extremely gcn5 ic50 kat3b kat5 kat6b l002 mb mda methyltransferases mumol nci nsc764414 paralog potently throughput tnbc xenografts	accessible applicable cancerous chosen constitute crc csnk1e ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs ranked rb1 rko rnai sl synergistically top tp53 uncovering verified wnt5a
Tagcloud (Intersection) ?		therapeutics