KAT7 and CDC6

Number of citations of the paper that reports this interaction (PMID 16428461)
38

Data Source:
BioGRID (enzymatic study)

		KAT7	CDC6
Gene Name		K(lysine) acetyltransferase 7	cell division cycle 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Nucleolus Cytoplasm	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	DNA Replication Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: APP AR ATN1 BARD1 CAAP1 CALCOCO2 CBX8 CDC6 CDK11B CEP70 CSNK1E DDX11 DVL3 DYNC1I1 GMNN HAP1 HIST1H3A HIST1H4A HIST2H2AC HOOK2 ING4 JADE1 KATNBL1 KCTD13 KIAA1377 LRIF1 MCM2 NINL ORC1 ORC2 PACSIN1 POLB PPID RGL2 RPS10 SAT1 SEPT5 SNAPIN TP53 VIM WDR33 ZBTB8A ZNF165	36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1
Entrez ID		11143	990
HPRD ID		07135	04022
Ensembl ID		ENSG00000136504	ENSG00000094804
Uniprot IDs		O95251	Q99741
PDB IDs			2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA-dependent DNA Replication Negative Regulation Of Biosynthetic Process Neuron Apoptotic Process Regulation Of RNA Metabolic Process Apoptotic Process Neuron Death Programmed Cell Death Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Replication Initiation Regulation Of Cell Cycle Establishment Of Vesicle Localization Vesicle Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Viral Process Chromosome Organization Regulation Of Cell Cycle Phase Transition Cellular Macromolecule Biosynthetic Process Cellular Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of DNA Replication Negative Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Microtubule-based Transport	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process
Tagcloud ?		acetyltransferase acetyltransferases analogs anticancer assayed campaign cascades deacetylases discover docked extremely gcn5 ic50 kat3b kat5 kat6b l002 mb mda methyltransferases mumol nci nsc764414 paralog potently therapeutics throughput tnbc xenografts	antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Difference) ?		acetyltransferase acetyltransferases analogs anticancer assayed campaign cascades deacetylases discover docked extremely gcn5 ic50 kat3b kat5 kat6b l002 mb mda methyltransferases mumol nci nsc764414 paralog potently therapeutics throughput tnbc xenografts	antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Intersection) ?