CAT and EHHADH

Number of citations of the paper that reports this interaction (PMID 16781659)
6

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)

		CAT	EHHADH
Gene Name		catalase	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Mitochondrion Peroxisome Cytosol
	Molecular Function	Aminoacylase Activity Catalase Activity Receptor Binding Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Dodecenoyl-CoA Delta-isomerase Activity Enoyl-CoA Hydratase Activity Receptor Binding Enzyme Binding Coenzyme Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration UV Protection Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Vitamin E Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Tetramerization Protein Homotetramerization Positive Regulation Of Cell Division Nucleobase-containing Small Molecule Metabolic Process Response To Hyperoxia Cellular Response To Growth Factor Stimulus	Internal Protein Amino Acid Acetylation Fatty Acid Beta-oxidation
Pathways		Purine catabolism Purine metabolism Detoxification of Reactive Oxygen Species Metabolism of nucleotides
Drugs		Fomepizole Heme	NADH
Diseases
GWAS			Cognitive performance ( 19734545) Major depressive disorder ( 21042317)
Protein-Protein Interactions		8 interactors: ABL1 ABL2 APP EHHADH KEAP1 PTPN11 SUMO4 TLR10	27 interactors: ACTB ACTG1 BHLHE40 CAT CBS CCDC102B DES FUNDC1 KCTD6 KCTD9 KRTAP10-7 LZTS2 MID1 NECAB2 PNMA1 SCP2 SSNA1 SSX2IP TNIP1 TPP2 TRAF1 TRIM27 TRIM41 TRIM54 TRIM55 TRIM63 ZBTB9
Entrez ID		847	1962
HPRD ID		00282	06125
Ensembl ID		ENSG00000121691	ENSG00000113790
Uniprot IDs		P04040	Q08426 Q9NY65
PDB IDs		1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Secretion Collateral Sprouting Neuromuscular Process Controlling Balance Bergmann Glial Cell Differentiation Innate Immune Response Neuron Remodeling Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Axon Guidance Regulation Of Protein Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of ERK1 And ERK2 Cascade Neuromuscular Process Regulation Of Cytokine Secretion Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Axonogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Immune Response Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Defense Response Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Protein Transport Regulation Of Secretion Neuron Projection Morphogenesis Negative Regulation Of Cell Adhesion Regulation Of Establishment Of Protein Localization Neuron Maturation Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Brain Development Peptidyl-tyrosine Autophosphorylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Extracellular Matrix Organization Positive Regulation Of Oxidoreductase Activity Regulation Of Protein Localization Head Development Astrocyte Differentiation Neuron Projection Development Positive Regulation Of Cell Cycle Cell Projection Morphogenesis Cellular Calcium Ion Homeostasis	Cellular Component Assembly Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Complex Assembly Organelle Organization Negative Regulation Of Microtubule Depolymerization Intraciliary Transport Cytoskeleton Organization Purine Nucleotide Catabolic Process Platelet Aggregation Protein Oligomerization Microtubule-based Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Cysteine Biosynthetic Process From Serine Lipid Hydroperoxide Transport Positive Regulation Of Intracellular Cholesterol Transport Homocysteine Catabolic Process Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Cysteine Biosynthetic Process Via Cystathionine Response To Stimulus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Serine Family Amino Acid Metabolic Process Defense Response Retina Homeostasis Protein Homooligomerization Signal Transduction Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Interleukin-2 Secretion Transsulfuration Protein Ubiquitination Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Viral Process Nucleotide Catabolic Process Protein Modification By Small Protein Conjugation Depurination Cysteine Biosynthetic Process L-cysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Adherens Junction Organization Signaling Immune System Process L-serine Catabolic Process Inositol Trisphosphate Biosynthetic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Stress Negative Regulation Of Protein Complex Disassembly Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Communication Cellular Response To Stimulus Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway
Tagcloud ?		alternatives chloramphenicol competition constructs designated electrophoretic element emsa exactly flanking gggaaggcggagtcc ggrgyyn ifn inducibility inducible isre kcs mutagenesis mutational nnrrrgg pkr possessing purine pyrimidine replaced stands tata transfection whereby	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		alternatives chloramphenicol competition constructs designated electrophoretic element emsa exactly flanking gggaaggcggagtcc ggrgyyn ifn inducibility inducible isre kcs mutagenesis mutational nnrrrgg pkr possessing purine pyrimidine replaced stands tata transfection whereby	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?