CAT and SUMO4

Number of citations of the paper that reports this interaction (PubMedID 16236267)
0

Data Source:
HPRD (in vivo)

		CAT	SUMO4
Description		catalase	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Catalase Complex Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus SUMO Ligase Complex
	Molecular Function	Aminoacylase Activity Catalase Activity Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding	Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Kidney Development Triglyceride Metabolic Process Response To Oxidative Stress Cholesterol Metabolic Process Aerobic Respiration Response To Xenobiotic Stimulus Response To UV Response To Toxic Substance Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Response To Activity Response To Inactivity Hemoglobin Metabolic Process Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Response To Ethanol Response To Cadmium Ion Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Hyperoxia Cellular Detoxification Of Hydrogen Peroxide Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Amitrole Response To Phenylpropanoid	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleus
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)
Drugs		Fomepizole Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases		Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS		Blood protein levels ( 30072576)	Dupuytren's disease ( 28886342)
Interacting Genes		9 interacting genes: ABL1 ABL2 APP EHHADH KEAP1 OGT PTPN11 SUMO4 TLR10	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB1 PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		847	387082
HPRD ID		00282	10584
Ensembl ID		ENSG00000121691	ENSG00000177688
Uniprot IDs		A0A384P5Q0 P04040	Q6EEV6
PDB IDs		1DGB 1DGF 1DGG 1DGH 1F4J 1QQW 7P8W 7VD9 8EL9 8HID 8PVD 8SGV 8WZH 8WZJ 8WZK 8WZM
Enriched GO Terms of Interacting Partners?		Cellular Response To Oxidative Stress Cellular Response To Chemical Stress Response To Stress Positive Regulation Of T Cell Migration Enzyme Binding Phosphotyrosine Residue Binding Protein-containing Complex Positive Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Regulation Of Intracellular Signal Transduction Response To Oxidative Stress Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of T Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphocyte Migration ERBB Signaling Pathway Enzyme Activator Activity Bergmann Glial Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Positive Regulation Of Cell-cell Adhesion Cellular Response To Catecholamine Stimulus Positive Regulation Of Mitotic Cell Cycle Response To Catecholamine Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Mononuclear Cell Migration Regulation Of Establishment Of Cell Polarity Insulin Receptor Binding Positive Regulation Of Leukocyte Migration Actin Monomer Binding Cell Activation Involved In Immune Response Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of MAPK Cascade Ephrin Receptor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Hemopoiesis Cellular Response To Stress Astrocyte Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway	Extracellular Exosome Protein Folding ATP-dependent Protein Folding Chaperone Unfolded Protein Binding Protein Folding Chaperone Cytoplasm Purine Nucleotide Metabolic Process Cytosol Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Ribose Phosphate Metabolic Process Regulation Of Apoptotic Process Ficolin-1-rich Granule Lumen Purine-containing Compound Metabolic Process Regulation Of Programmed Cell Death Identical Protein Binding RNA Binding Nucleoside Phosphate Metabolic Process Nicotinamide Nucleotide Metabolic Process Protein Refolding ATP Metabolic Process Secretory Granule Lumen Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Peroxiredoxin Activity Ribonucleotide Metabolic Process Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Telomerase RNA Localization To Cajal Body Mitochondrion Positive Regulation Of Telomere Maintenance Via Telomerase Oxidoreductase Activity Antioxidant Activity Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoprotein Complex Small Molecule Metabolic Process Generation Of Precursor Metabolites And Energy Response To Peptide Enzyme Binding Regulation Of Telomerase RNA Localization To Cajal Body Peroxidase Activity Nucleus Hydrogen Peroxide Metabolic Process Response To Stress Organophosphate Metabolic Process
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