CAT and ABL2

Number of citations of the paper that reports this interaction (PMID 12777400)
18

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)
HPRD (in vivo, in vitro)

		CAT	ABL2
Gene Name		catalase	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Phagocytic Cup Cytosol Actin Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine
	Molecular Function	Aminoacylase Activity Catalase Activity Receptor Binding Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding	Magnesium Ion Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration UV Protection Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Vitamin E Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Tetramerization Protein Homotetramerization Positive Regulation Of Cell Division Nucleobase-containing Small Molecule Metabolic Process Response To Hyperoxia Cellular Response To Growth Factor Stimulus	Cellular Protein Modification Process Phagocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Neuron Remodeling Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Regulation Of Endocytosis Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Cellular Protein Localization Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Neuromuscular Process Controlling Balance Actin Filament Bundle Assembly Positive Regulation Of Oxidoreductase Activity Bergmann Glial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Dendritic Spine Maintenance Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Purine catabolism Purine metabolism Detoxification of Reactive Oxygen Species Metabolism of nucleotides	Role of Abl in Robo-Slit signaling Axon guidance Signaling by Robo receptor
Drugs		Fomepizole Heme	Adenosine triphosphate Dasatinib 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS			IgE grass sensitization ( 22036096)
Protein-Protein Interactions		8 interactors: ABL1 ABL2 APP EHHADH KEAP1 PTPN11 SUMO4 TLR10	25 interactors: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 NEDD4 NEDD4L OIP5 PSMA7 RIN1 SIVA1 SORBS2 TPD52L1 TRIP10
Entrez ID		847	27
HPRD ID		00282	01259
Ensembl ID		ENSG00000121691	ENSG00000143322
Uniprot IDs		P04040	P42684
PDB IDs		1DGB 1DGF 1DGG 1DGH 1F4J 1QQW	2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Secretion Collateral Sprouting Neuromuscular Process Controlling Balance Bergmann Glial Cell Differentiation Innate Immune Response Neuron Remodeling Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Axon Guidance Regulation Of Protein Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of ERK1 And ERK2 Cascade Neuromuscular Process Regulation Of Cytokine Secretion Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Axonogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Immune Response Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Defense Response Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Protein Transport Regulation Of Secretion Neuron Projection Morphogenesis Negative Regulation Of Cell Adhesion Regulation Of Establishment Of Protein Localization Neuron Maturation Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Brain Development Peptidyl-tyrosine Autophosphorylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Extracellular Matrix Organization Positive Regulation Of Oxidoreductase Activity Regulation Of Protein Localization Head Development Astrocyte Differentiation Neuron Projection Development Positive Regulation Of Cell Cycle Cell Projection Morphogenesis Cellular Calcium Ion Homeostasis	Regulation Of Signaling Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Communication Protein Autophosphorylation Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Signaling Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Locomotion Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Growth Factor Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Immune System Process Positive Regulation Of MAPK Cascade Cellular Protein Modification Process Regulation Of Protein Metabolic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Response To Stimulus Positive Regulation Of Metabolic Process Response To Stress Regulation Of Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		alternatives chloramphenicol competition constructs designated electrophoretic element emsa exactly flanking gggaaggcggagtcc ggrgyyn ifn inducibility inducible isre kcs mutagenesis mutational nnrrrgg pkr possessing purine pyrimidine replaced stands tata transfection whereby	abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Difference) ?		alternatives chloramphenicol competition constructs designated electrophoretic element emsa exactly flanking gggaaggcggagtcc ggrgyyn ifn inducibility inducible isre kcs mutagenesis mutational nnrrrgg pkr possessing purine pyrimidine replaced stands tata transfection whereby	abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Intersection) ?