CAT

Name	catalase
Structure
Novel Interactors	2 novel interactors: CD44 PRKRA
Interactors	9 interactors: ABL1 ABL2 APP EHHADH KEAP1 OGT PTPN11 SUMO4 TLR10
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Catalase Complex Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Aminoacylase Activity Catalase Activity Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding
	Biological Process	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Kidney Development Triglyceride Metabolic Process Response To Oxidative Stress Cholesterol Metabolic Process Aerobic Respiration Response To Xenobiotic Stimulus Response To UV Response To Toxic Substance Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Response To Activity Response To Inactivity Hemoglobin Metabolic Process Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Response To Ethanol Response To Cadmium Ion Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Hyperoxia Cellular Detoxification Of Hydrogen Peroxide Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Amitrole Response To Phenylpropanoid
Pathways	Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)
Drugs	Fomepizole Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases	Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS	Blood protein levels ( 30072576 )
Entrez ID	847
HPRD ID	00282
Ensembl ID	ENSG00000121691
Uniprot IDs	A0A384P5Q0 P04040
PDB IDs	1DGB 1DGF 1DGG 1DGH 1F4J 1QQW 7P8W 7VD9 8EL9 8HID 8PVD 8SGV 8WZH 8WZJ 8WZK 8WZM
GO Terms Enriched among Interactors ?	Cellular Response To Oxidative Stress Cellular Response To Chemical Stress Response To Stress Positive Regulation Of T Cell Migration Enzyme Binding Phosphotyrosine Residue Binding Protein-containing Complex Positive Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Regulation Of Intracellular Signal Transduction Response To Oxidative Stress Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of T Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphocyte Migration ERBB Signaling Pathway Enzyme Activator Activity Bergmann Glial Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Positive Regulation Of Cell-cell Adhesion Cellular Response To Catecholamine Stimulus Positive Regulation Of Mitotic Cell Cycle Response To Catecholamine Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Mononuclear Cell Migration Regulation Of Establishment Of Cell Polarity Insulin Receptor Binding Positive Regulation Of Leukocyte Migration Actin Monomer Binding Cell Activation Involved In Immune Response Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of MAPK Cascade Ephrin Receptor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Hemopoiesis Cellular Response To Stress Astrocyte Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway