PAK3 and ARHGEF7

Number of citations of the paper that reports this interaction (PubMedID 9726964)
0

Data Source:
HPRD (in vivo)

		PAK3	ARHGEF7
Description		p21 (RAC1) activated kinase 3	Rho guanine nucleotide exchange factor 7
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse	Ruffle Cytoplasm Centrosome Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Cell Projection Neuron Projection Neuronal Cell Body Anchoring Junction Mitotic Spindle Pole Postsynapse
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Gamma-tubulin Binding
	Biological Process	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Cellular Response To Starvation Dendrite Development Cell Migration Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization Dendritic Spine Development Dendritic Spine Morphogenesis Regulation Of Postsynapse Organization Regulation Of Actin Filament Organization	Golgi Organization Signal Transduction Rho Protein Signal Transduction Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Microtubule Nucleation Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle	EGFR downregulation NRAGE signals death through JNK Ephrin signaling G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs		Fostamatinib
Diseases		Non-syndromic X-linked mental retardation
GWAS			Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824) Weight ( 34074324)
Interacting Genes		13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1	37 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN FXR1 FXR2 GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PRRG4 PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 VHL WAS YWHAG
Entrez ID		5063	8874
HPRD ID		02142	05688
Ensembl ID		ENSG00000077264	ENSG00000102606
Uniprot IDs		B2RCU6 O75914	A0A2R8YG42 A0A8V8TQ72 B1ALK7 B7Z344 B7Z6G2 E9PDQ5 Q14155
PDB IDs		6FD3	1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?		Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Lamellipodium Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Cell Cortex Lamellipodium Regulation Of Microtubule Polymerization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Postsynapse Cell Junction Organization Cell Projection Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Or Depolymerization Actin Filament Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Lamellipodium Organization Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Plasma Membrane Bounded Cell Projection Assembly Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Substrate Adhesion-dependent Cell Spreading Cell-cell Junction Endocytosis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Signal Complex Assembly Intracellular Signaling Cassette Presynapse Thioesterase Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Regulation Of Neurotransmitter Secretion Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Stress Fiber Assembly	Regulation Of Signaling Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Stress Fiber Assembly Postsynapse Regulation Of Cell Communication Regulation Of Actin Cytoskeleton Organization Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Cell-cell Junction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Signal Transduction Glutamatergic Synapse Positive Regulation Of Stress Fiber Assembly Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cytoskeleton Organization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Plasma Membrane Modulation Of Chemical Synaptic Transmission Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Small GTPase Binding SH3 Domain Binding Lamellipodium Regulation Of Synaptic Plasticity Cytosol Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Dendrite Neuron Projection Regulation Of Organelle Organization Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Organelle Organization Protein Localization To Cell Junction Postsynaptic Density Positive Regulation Of T Cell Tolerance Induction Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Locomotion
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