PAK3 and GIT1

Number of citations of the paper that reports this interaction (PMID 10896954)
36

Data Source:
HPRD (in vivo)

		PAK3	GIT1
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 3	G protein-coupled receptor kinase interacting ArfGAP 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane	Cytoplasm Cytosol Focal Adhesion Membrane Aggresome
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Rho GTPase Binding SH3 Domain Binding Metal Ion Binding	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Mitotic Cell Cycle Protein Phosphorylation Axonogenesis Axon Guidance Dendrite Development Signal Transduction By Phosphorylation Regulation Of Actin Filament Polymerization T Cell Costimulation Positive Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synapse Organization T Cell Receptor Signaling Pathway Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of DNA Biosynthetic Process	Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway
Pathways		Generation of second messenger molecules Costimulation by the CD28 family Axon guidance Semaphorin interactions CD28 co-stimulation FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway CD28 dependent Vav1 pathway Ephrin signaling TCR signaling Activation of Rac Signaling by VEGF VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fc epsilon receptor (FCERI) signaling Sema3A PAK dependent Axon repulsion Signaling by Robo receptor Innate Immune System Adaptive Immune System	Ephrin signaling Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 SNCA SYN1	50 interactors: ADRBK1 ADRBK2 ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CHD3 DDX24 EIF6 GIT2 GRB2 GRK5 GRK6 HAP1 HMOX2 HTT KIAA1377 KIF1A LAMTOR5 LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SDCCAG3 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG
Entrez ID		5063	28964
HPRD ID		02142	06577
Ensembl ID		ENSG00000077264	ENSG00000108262
Uniprot IDs		B2RCU6 O75914	Q59FC3 Q9Y2X7
PDB IDs
Enriched GO Terms of Interacting Partners?		Lamellipodium Assembly Lamellipodium Organization Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Assembly Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Neuron Projection Development Movement Of Cell Or Subcellular Component Axonogenesis Neuron Development Ephrin Receptor Signaling Pathway Axon Development Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Chemotaxis Cell Morphogenesis Positive Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Neuron Differentiation Regulation Of Protein Complex Assembly Cell Development Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Component Assembly Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Cell Projection Morphogenesis Cell Communication Cell Part Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Kinase Activity Cell-cell Junction Organization Regulation Of Cell Death	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Termination Of Signal Transduction Glutamate Secretion Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signal Complex Assembly Regulation Of Neurotransmitter Levels Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Dicarboxylic Acid Transport Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotransmitter Secretion Regulation Of Kinase Activity Response To Peptide Hormone Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Cell-substrate Adhesion Regulation Of Apoptotic Process Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Response To Peptide Positive Regulation Of Signal Transduction Signaling Acid Secretion Negative Regulation Of Signal Transduction Regulation Of Phosphorylation
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1	ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Difference) ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1	ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Intersection) ?