PAK3 and GIT2

Number of citations of the paper that reports this interaction (PMID 10896954)
36

Data Source:
HPRD (in vivo)

		PAK3	GIT2
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 3	G protein-coupled receptor kinase interacting ArfGAP 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane	Nucleoplasm Focal Adhesion
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Rho GTPase Binding SH3 Domain Binding Metal Ion Binding	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Mitotic Cell Cycle Protein Phosphorylation Axonogenesis Axon Guidance Dendrite Development Signal Transduction By Phosphorylation Regulation Of Actin Filament Polymerization T Cell Costimulation Positive Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synapse Organization T Cell Receptor Signaling Pathway Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of DNA Biosynthetic Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Behavioral Response To Pain
Pathways		Generation of second messenger molecules Costimulation by the CD28 family Axon guidance Semaphorin interactions CD28 co-stimulation FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway CD28 dependent Vav1 pathway Ephrin signaling TCR signaling Activation of Rac Signaling by VEGF VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fc epsilon receptor (FCERI) signaling Sema3A PAK dependent Axon repulsion Signaling by Robo receptor Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS			Metabolic syndrome ( 20694148) Metabolite levels (MHPG) ( 23319000)
Protein-Protein Interactions		12 interactors: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 SNCA SYN1	44 interactors: ACTG1 ACTN1 ADRBK1 ARHGEF7 ATF5 C4BPA CALCOCO2 CORO1A E2F2 EDC4 GCH1 GIT1 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG
Entrez ID		5063	9815
HPRD ID		02142	09779
Ensembl ID		ENSG00000077264	ENSG00000139436
Uniprot IDs		B2RCU6 O75914	F8VXI9 Q14161 Q6FI58
PDB IDs
Enriched GO Terms of Interacting Partners?		Lamellipodium Assembly Lamellipodium Organization Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Assembly Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Neuron Projection Development Movement Of Cell Or Subcellular Component Axonogenesis Neuron Development Ephrin Receptor Signaling Pathway Axon Development Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Chemotaxis Cell Morphogenesis Positive Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Neuron Differentiation Regulation Of Protein Complex Assembly Cell Development Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Component Assembly Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signaling Cell Projection Morphogenesis Cell Communication Cell Part Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Kinase Activity Cell-cell Junction Organization Regulation Of Cell Death	Regulation Of Apoptotic Process Regulation Of Cell Death Ephrin Receptor Signaling Pathway Innate Immune Response Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Signal Transduction Immune System Process Immune Response Regulation Of Immune System Process Cell Death Regulation Of Metabolic Process Death Positive Regulation Of Immune Response Defense Response Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Adherens Junction Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune System Process Focal Adhesion Assembly Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Organization Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Signaling Regulation Of Kinase Activity Cellular Component Assembly Cell Communication Regulation Of Phosphorylation Adherens Junction Assembly Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Cell Development Cell-substrate Junction Assembly Activation Of MAPK Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Stress Activation Of Innate Immune Response Cell Surface Receptor Signaling Pathway
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1	ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Difference) ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pathoetiology plcb1 pxn skew sos1 unacclimatized vasoconstriction vcam1	ancient autophosphorylation coordinates deregulated dimerization exchange gef git1 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Intersection) ?