EDC4 and YTHDC1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EDC4	YTHDC1
Gene Name		enhancer of mRNA decapping 4	YTH domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Nucleus Nuclear Body
	Molecular Function	Protein Binding	RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Biological_process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	MRNA Splice Site Selection
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282) Metabolic syndrome ( 22399527)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: CCL5 EIF2AK2 FBLN1 GIT2 YTHDC1	34 interactors: ABL1 ADAMTS4 CFH CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 LAMC3 LAMTOR5 LZTS2 MPRIP PLG PROSER2 RBMY1F SDCBP2 SEPT10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51
Entrez ID		23644	91746
HPRD ID		06911	11689
Ensembl ID		ENSG00000038358	ENSG00000083896
Uniprot IDs		Q6P2E9	J3QR07 Q96MU7
PDB IDs			2YUD
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Viral Genome Replication Regulation Of Viral Genome Replication Positive Regulation Of Catalytic Activity Regulation Of Translational Initiation Negative Regulation Of Viral Process Evasion Or Tolerance By Virus Of Host Immune Response Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Viral Process Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Hydrolase Activity Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Activation Of JAK2 Kinase Activity Response To Virus Positive Regulation Of Protein Metabolic Process Regulation Of Translation Positive Regulation Of Activation Of Janus Kinase Activity Response To Host Immune Response Positive Regulation Of Macrophage Chemotaxis Regulation Of NLRP3 Inflammasome Complex Assembly Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of T Cell Chemotaxis Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Metabolic Process Negative Regulation By Host Of Viral Transcription Positive Regulation Of Monocyte Chemotaxis Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Osteoblast Proliferation Modulation By Virus Of Host Process Regulation Of Chronic Inflammatory Response Regulation Of Macrophage Chemotaxis Regulation Of Monocyte Chemotaxis Positive Regulation Of Translational Initiation Dendritic Cell Chemotaxis Activation Of Phospholipase D Activity Positive Regulation Of T Cell Apoptotic Process Monocyte Chemotaxis Regulation Of Macrophage Apoptotic Process Regulation Of Translation In Response To Stress Response To Interferon-alpha Posttranscriptional Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction	MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Protein Autophosphorylation Regulation Of Cell-cell Adhesion RNA Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Wnt Signaling Pathway Gene Expression Viral Process Innate Immune Response Regulation Of Cell Proliferation Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Cell Adhesion Anatomical Structure Development Leukocyte Migration Regulation Of Canonical Wnt Signaling Pathway Immune Response Regulation Of RNA Metabolic Process Regulation Of Intracellular Transport Cytoplasmic Transport Defense Response Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Localization Activated T Cell Proliferation Phagocytosis Positive Regulation Of Viral Genome Replication Regulation Of Neuron Death Heterocycle Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Aromatic Compound Metabolic Process Nuclear Export Regulation Of T Cell Activation Nucleus Organization Regulation Of Gene Expression Developmental Process Regulation Of Nitrogen Compound Metabolic Process Antigen Receptor-mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Cellular Process Golgi To Plasma Membrane Transport
Tagcloud ?		bodies coimmunoprecipitated collectively colocalized dcp1a decapping dispersion effectors ikappabalpha inducers jnk jun localization messenger multifunctional overexpressed p65 phosphomimetic residue ribonucleic s315 stabilized stimuli subcellular sustained tak1 transcriptome transiently xrn1
Tagcloud (Difference) ?		bodies coimmunoprecipitated collectively colocalized dcp1a decapping dispersion effectors ikappabalpha inducers jnk jun localization messenger multifunctional overexpressed p65 phosphomimetic residue ribonucleic s315 stabilized stimuli subcellular sustained tak1 transcriptome transiently xrn1
Tagcloud (Intersection) ?