EDC4 and MIR92A1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		EDC4	MIR92A1
Description		enhancer of mRNA decapping 4	microRNA 92a-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	Extracellular Space Cytoplasm RISC Complex Extracellular Vesicle
	Molecular Function	Protein Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Acute Inflammatory Response Regulation Of Heart Contraction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Fatty Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Stress Response To Acid Chemical Vascular Endothelial Cell Response To Fluid Shear Stress Blood Vessel Diameter Maintenance Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Endothelial Cell Activation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Pathways		mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		HDL cholesterol ( 21347282) Metabolic syndrome ( 22399527) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		42 interacting genes: CCL5 CDC42 CEBPA EIF2AK2 FBLN1 FXR1 FXR2 GIT2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR122 MIR128-2 MIR141 MIR15B MIR199A1 MIR200A MIR200B MIR200C MIR205 MIR20A MIR21 MIR214 MIR222 MIR29C MIR34A MIR34C MIR363 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E SNCA SUMO2 YTHDC1	76 interacting genes: ADARB1 C1QBP CELF1 CPSF1 CPSF2 CPSF6 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LRPPRC MATR3 MSI2 NOL6 NONO NUDT21 P3H1 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 QARS1 RARS1 RBM14 RBM4 RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 WWP2 YBX1 YBX3
Entrez ID		23644	407048
HPRD ID		06911
Ensembl ID		ENSG00000038358	ENSG00000283705
Uniprot IDs		A0A8B0RAT7 Q6P2E9
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization Regulation Of Translation RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Protein Metabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Signal Transduction Extracellular Space Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Angiogenesis Regulation Of Protein Metabolic Process Negative Regulation Of Vasculature Development Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Catabolic Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Population Proliferation Regulation Of Vasculature Development	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Splicing Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Nucleoplasm Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule MRNA 3'-UTR Binding Regulation Of Translation Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Negative Regulation Of Translation Regulation Of MRNA Stability MRNA Cleavage And Polyadenylation Specificity Factor Complex Regulation Of Primary Metabolic Process Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Paraspeckles Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation CRD-mediated MRNA Stabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-UTR Binding RNA Transport Positive Regulation Of Gene Expression
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