EDC4 and FBLN1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EDC4	FBLN1
Description		enhancer of mRNA decapping 4	fibulin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Protein Binding	Fibronectin Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding
	Biological Process	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Gene Expression Extracellular Matrix Organization Positive Regulation Of Fibroblast Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation
Pathways		mRNA decay by 5' to 3' exoribonuclease	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		HDL cholesterol ( 21347282) Metabolic syndrome ( 22399527) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Blood protein levels ( 30072576) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		42 interacting genes: CCL5 CDC42 CEBPA EIF2AK2 FBLN1 FXR1 FXR2 GIT2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR122 MIR128-2 MIR141 MIR15B MIR199A1 MIR200A MIR200B MIR200C MIR205 MIR20A MIR21 MIR214 MIR222 MIR29C MIR34A MIR34C MIR363 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E SNCA SUMO2 YTHDC1	66 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CRIPTO CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 FXR1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KLHL20 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1D LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 NUFIP2 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TRIM42 UNKL VCAN YWHAQ
Entrez ID		23644	2192
HPRD ID		06911	00629
Ensembl ID		ENSG00000038358	ENSG00000077942
Uniprot IDs		A0A8B0RAT7 Q6P2E9	A0A8S0LWY1 P23142 Q8NBH6
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization Regulation Of Translation RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Protein Metabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Signal Transduction Extracellular Space Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Angiogenesis Regulation Of Protein Metabolic Process Negative Regulation Of Vasculature Development Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Catabolic Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Population Proliferation Regulation Of Vasculature Development	Extracellular Matrix Tissue Development Epidermis Development Keratinization Extracellular Matrix Structural Constituent Developmental Process Integrin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Signal Transduction Response To Interleukin-1 Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Cell Migration Negative Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Angiogenesis Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of System Process Anatomical Structure Formation Involved In Morphogenesis Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Development Calcium-independent Cell-matrix Adhesion Embryonic Pattern Specification Adrenal Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding Extracellular Region Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Collagen Binding Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of MiRNA Transcription Cell Migration Regulation Of Spontaneous Synaptic Transmission Activin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process
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