DLGAP5 and TRIM37

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLGAP5	TRIM37
Gene Name		discs, large (Drosophila) homolog-associated protein 5	tripartite motif containing 37
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Organizing Center Spindle Pole Centrosome	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Chromosome Movement Towards Spindle Pole Cell-cell Signaling Cell Proliferation Dephosphorylation Positive Regulation Of Mitotic Metaphase/anaphase Transition	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Protein biomarker ( 23056639)	Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		6 interactors: APP BTRC GOLGA2 MTUS2 TRAF2 TRIM37	59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655
Entrez ID		9787	4591
HPRD ID		06490	05463
Ensembl ID		ENSG00000126787	ENSG00000108395
Uniprot IDs		Q15398	A8K0V9 A8K8U4 F8WEE6 O94972
PDB IDs			3LRQ
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding Regulation Of Binding Positive Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autoubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Protein Polyubiquitination Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Histone H2A-K119 Monoubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Negative Regulation Of Glial Cell Apoptotic Process Cellular Protein Modification Process Neuron Remodeling Positive Regulation Of Protein Homodimerization Activity Cellular Response To Nitric Oxide Regulation Of Centriole Replication Histone H2A Monoubiquitination Aggresome Assembly Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Regulation Of Peptidase Activity Response To Oxidative Stress Histone H2A Ubiquitination Negative Regulation Of Centrosome Duplication Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Circadian Rhythm Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Cellular Copper Ion Homeostasis Regulation Of Protein Homodimerization Activity Regulation Of Cell Cycle Process Cellular Response To Reactive Nitrogen Species Histone Monoubiquitination Cellular Component Assembly	Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process
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