ECE2 and SYNE4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ECE2	SYNE4
Gene Name		endothelin converting enzyme 2	spectrin repeat containing, nuclear envelope family member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Integral Component Of Nuclear Outer Membrane LINC Complex
	Molecular Function	Metalloendopeptidase Activity Methyltransferase Activity Metal Ion Binding
	Biological Process	Proteolysis Cell-cell Signaling Brain Development Heart Development Cardioblast Differentiation Peptide Hormone Processing Methylation	Establishment Of Epithelial Cell Apical/basal Polarity
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876) Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		4 interactors: CASP10 CD86 SYNE4 UBC	52 interactors: ABT1 ADIPOQ BRICD5 C10orf35 C3orf52 CD47 CEP19 CLDN7 CLDN8 CLEC7A CMTM5 CSGALNACT2 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FATE1 GADD45A GSK3B ITM2B KLC4 KLHL12 KLRG1 KTN1 MALL MARCH2 NAGK OCLN OLFM4 OSTCP1 PAQR5 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250
Entrez ID		9718	163183
HPRD ID		09931	08776
Ensembl ID		ENSG00000145194	ENSG00000181392
Uniprot IDs		O60344	Q8N205
PDB IDs		2PXX
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Innate Immune Response Defense Response Fc Receptor Signaling Pathway Establishment Of Epithelial Cell Apical/basal Polarity Response To Yeast Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of T Cell Anergy Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Establishment Of Monopolar Cell Polarity Viral Protein Processing Immune Response-regulating Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Immune System Process Establishment Of Epithelial Cell Polarity Regulation Of Cytokine Production Viral Process Positive Regulation Of T-helper 2 Cell Differentiation Cellular Response To Growth Factor Stimulus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cellular Response To Cytokine Stimulus Response To Growth Factor Notch Receptor Processing Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-4 Production Virion Assembly Regulation Of Interleukin-2 Biosynthetic Process	ER To Golgi Vesicle-mediated Transport Negative Regulation Of Binding Regulation Of Binding Golgi Vesicle Transport Adiponectin-activated Signaling Pathway Vesicle Fusion With Golgi Apparatus Negative Regulation Of Protein Binding Response To External Stimulus Regulation Of Glycogen (starch) Synthase Activity Cellular Response To Mechanical Stimulus Vesicle-mediated Transport Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Intracellular Signal Transduction
Tagcloud ?		arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver eppk1 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover
Tagcloud (Difference) ?		arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver eppk1 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover
Tagcloud (Intersection) ?