ECE2 and CASP10

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ECE2	CASP10
Gene Name		endothelin converting enzyme 2	caspase 10, apoptosis-related cysteine peptidase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Cytoplasm Cytosol Plasma Membrane CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Metalloendopeptidase Activity Methyltransferase Activity Metal Ion Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	Proteolysis Cell-cell Signaling Brain Development Heart Development Cardioblast Differentiation Peptide Hormone Processing Methylation	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Apoptotic Signaling Pathway
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAIL signaling Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876) Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		4 interactors: CASP10 CD86 SYNE4 UBC	30 interactors: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		9718	843
HPRD ID		09931	03458
Ensembl ID		ENSG00000145194	ENSG00000003400
Uniprot IDs		O60344	Q92851
PDB IDs		2PXX
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Innate Immune Response Defense Response Fc Receptor Signaling Pathway Establishment Of Epithelial Cell Apical/basal Polarity Response To Yeast Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of T Cell Anergy Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Establishment Of Monopolar Cell Polarity Viral Protein Processing Immune Response-regulating Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Immune System Process Establishment Of Epithelial Cell Polarity Regulation Of Cytokine Production Viral Process Positive Regulation Of T-helper 2 Cell Differentiation Cellular Response To Growth Factor Stimulus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cellular Response To Cytokine Stimulus Response To Growth Factor Notch Receptor Processing Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-4 Production Virion Assembly Regulation Of Interleukin-2 Biosynthetic Process	Apoptotic Process Programmed Cell Death Cell Death Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Execution Phase Of Apoptosis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Protein Processing Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Apoptotic Process Intracellular Signal Transduction Proteolysis Regulation Of Necroptotic Process Positive Regulation Of Neuron Apoptotic Process Neuron Death Regulation Of Cellular Protein Metabolic Process Hepatocyte Apoptotic Process Signaling Positive Regulation Of Neuron Death
Tagcloud ?		arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver eppk1 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover	arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Difference) ?		arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver eppk1 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover	arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Intersection) ?