ECE2

Gene Name		endothelin converting enzyme 2
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Metalloendopeptidase Activity Methyltransferase Activity Metal Ion Binding
	Biological Process	Proteolysis Cell-cell Signaling Brain Development Heart Development Cardioblast Differentiation Peptide Hormone Processing Methylation
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876) Menarche (age at onset) ( 21102462)
Protein-protein Interactions		4 interactors: CASP10 CD86 SYNE4 UBC
Entrez ID		9718
HPRD ID		09931
Ensembl ID		ENSG00000145194
Uniprot IDs		O60344
PDB IDs		2PXX
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Innate Immune Response Defense Response Fc Receptor Signaling Pathway Establishment Of Epithelial Cell Apical/basal Polarity Response To Yeast Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of T Cell Anergy Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Establishment Of Monopolar Cell Polarity Viral Protein Processing Immune Response-regulating Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Immune System Process Establishment Of Epithelial Cell Polarity Regulation Of Cytokine Production Viral Process Positive Regulation Of T-helper 2 Cell Differentiation Cellular Response To Growth Factor Stimulus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cellular Response To Cytokine Stimulus Response To Growth Factor Notch Receptor Processing Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-4 Production Virion Assembly Regulation Of Interleukin-2 Biosynthetic Process
Tagcloud ?		arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver eppk1 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover