ECE2 and CD86

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ECE2	CD86
Gene Name		endothelin converting enzyme 2	CD86 molecule
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Methyltransferase Activity Metal Ion Binding	Receptor Activity Receptor Binding Protein Binding Coreceptor Activity
	Biological Process	Proteolysis Cell-cell Signaling Brain Development Heart Development Cardioblast Differentiation Peptide Hormone Processing Methylation	Response To Yeast Toll-like Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Negative Regulation Of T Cell Anergy Immune Response Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Viral Process T Cell Costimulation Response To Interferon-gamma Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Metal Ion Cellular Response To Cytokine Stimulus
Pathways			Signaling by the B Cell Receptor (BCR) Costimulation by the CD28 family Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CTLA4 inhibitory signaling CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CD28 dependent Vav1 pathway Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Antithymocyte globulin Abatacept Belatacept
Diseases
GWAS		Major depressive disorder ( 22472876) Menarche (age at onset) ( 21102462)	Multiple sclerosis ( 22190364 21833088)
Protein-Protein Interactions		4 interactors: CASP10 CD86 SYNE4 UBC	6 interactors: CD28 CD80 CTLA4 ECE2 MARCH8 PARP1
Entrez ID		9718	942
HPRD ID		09931	03011
Ensembl ID		ENSG00000145194	ENSG00000114013
Uniprot IDs		O60344	A8K632 P42081
PDB IDs		2PXX	1I85 1NCN
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Innate Immune Response Negative Regulation Of T Cell Anergy Positive Regulation Of Lymphotoxin A Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Innate Immune Response Defense Response Fc Receptor Signaling Pathway Establishment Of Epithelial Cell Apical/basal Polarity Response To Yeast Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of T Cell Anergy Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Proliferation Involved In Immune Response Establishment Of Monopolar Cell Polarity Viral Protein Processing Immune Response-regulating Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Immune System Process Establishment Of Epithelial Cell Polarity Regulation Of Cytokine Production Viral Process Positive Regulation Of T-helper 2 Cell Differentiation Cellular Response To Growth Factor Stimulus Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cellular Response To Cytokine Stimulus Response To Growth Factor Notch Receptor Processing Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-4 Production Virion Assembly Regulation Of Interleukin-2 Biosynthetic Process	T Cell Costimulation Regulation Of T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cytokine Biosynthetic Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Immune Response Regulation Of T Cell Differentiation Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Growth Rate Protein Poly-ADP-ribosylation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Adaptive Immune Response Positive Regulation Of Immune System Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Regulatory T Cell Differentiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T-helper 1 Cell Differentiation
Tagcloud ?		arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver eppk1 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover	amixl atl bc blast burkitt cd54 cd58 cd80 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Difference) ?		arid1a bisphosphate cholangiocarcinoma cirrhosis designing driver eppk1 exclusively fatal fyn hbsag icc idh1 intrahepatic kras matching mutational phosphatidylinositol plc plcs seronegative seropositive signalling signature smad substantially tp53 transforming uncover	amixl atl bc blast burkitt cd54 cd58 cd80 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
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