HDAC10

Gene Name		histone deacetylase 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Histone Deacetylase Activity Protein Binding Enzyme Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Deacetylation Notch Signaling Pathway Oligodendrocyte Development Chromatin Modification Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Chromatin organization HDACs deacetylate histones Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: HDAC2 HDAC3 HSPA8 MDC1 NCOR2 PAX3 TRIM28
Entrez ID		83933
HPRD ID		09407
Ensembl ID		ENSG00000100429
Uniprot IDs		C9J8B8 Q969S8
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone H4 Deacetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Histone H3 Deacetylation Nitrogen Compound Metabolic Process RNA Metabolic Process Histone H3-K9 Modification Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Gene Expression Rhythmic Process Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone Deacetylation Cellular Response To Heat Epithelium Development Protein Deacetylation Embryo Development Anatomical Structure Morphogenesis Circadian Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Cycle Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibril Organization Heart Development Positive Regulation Of Protein Import Into Nucleus Biosynthetic Process Response To Heat Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus
Tagcloud ?		acetylated acetyltransferase alphav attachment cerebroside deacetylases dysregulation ebpalpha finger greatly hcc hdac9 hepatocellular implanted integrin intrahepatic intriguingly lost metastasis mir monocytic moz myst orthotopic orthotopically smmc sulfatide sulfotransferase verified