HDAC10 and HDAC2

Number of citations of the paper that reports this interaction (PMID 11739383)
24

Data Source:
HPRD (in vivo)

		HDAC10	HDAC2
Gene Name		histone deacetylase 10	histone deacetylase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Transcription Factor Complex Cytoplasm Sin3 Complex NuRD Complex ESC/E(Z) Complex Protein Complex
	Molecular Function	Histone Deacetylase Activity Protein Binding Enzyme Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Deacetylation Notch Signaling Pathway Oligodendrocyte Development Chromatin Modification Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Maintenance Of Chromatin Silencing Transcription, DNA-templated Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Gene Expression Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Neuron Projection Development Dendrite Development Histone Deacetylation Hippocampus Development Circadian Regulation Of Gene Expression Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Heat Regulation Of Gene Expression, Epigenetic Response To Cocaine Odontogenesis Of Dentin-containing Tooth Response To Drug Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Sarcomere Organization Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Deacetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Chromatin organization HDACs deacetylate histones Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NoRC negatively regulates rRNA expression Signaling by NOTCH1 Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Chromatin organization HDACs deacetylate histones p75NTR negatively regulates cell cycle via SC1 RNA Polymerase I Transcription Signaling by NOTCH Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression p75 NTR receptor-mediated signalling Factors involved in megakaryocyte development and platelet production NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: HDAC2 HDAC3 HSPA8 MDC1 NCOR2 PAX3 TRIM28	92 interactors: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 FKBP3 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LINC00152 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MTA2 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUV39H1 SYK TFCP2 THRA THRB TOP2A TOP2B TP53 VHL YY1 ZBTB16 ZNF461
Entrez ID		83933	3066
HPRD ID		09407	05521
Ensembl ID		ENSG00000100429	ENSG00000196591
Uniprot IDs		C9J8B8 Q969S8	Q92769
PDB IDs			3MAX 4LXZ 4LY1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone H4 Deacetylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Histone H3 Deacetylation Nitrogen Compound Metabolic Process RNA Metabolic Process Histone H3-K9 Modification Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Gene Expression Rhythmic Process Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone Deacetylation Cellular Response To Heat Epithelium Development Protein Deacetylation Embryo Development Anatomical Structure Morphogenesis Circadian Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Cycle Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibril Organization Heart Development Positive Regulation Of Protein Import Into Nucleus Biosynthetic Process Response To Heat Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Modification Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Organelle Organization Histone Modification Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Chromosome Organization Histone Deacetylation Protein Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Cycle
Tagcloud ?		acetylated acetyltransferase alphav attachment cerebroside deacetylases dysregulation ebpalpha finger greatly hcc hdac9 hepatocellular implanted integrin intrahepatic intriguingly lost metastasis mir monocytic moz myst orthotopic orthotopically smmc sulfatide sulfotransferase verified	abnormality accumbens ach3 adhd behavioural caudate deficit disrupted disruption dorsal exploratory habituation ht hydroxytryptamine hyperactivity mesocorticolimbic mesolimbic modulatory monoamine monoaminergic permanent putamen raphe serotonin tralpha tralpha0 trbeta trs
Tagcloud (Difference) ?		acetylated acetyltransferase alphav attachment cerebroside deacetylases dysregulation ebpalpha finger greatly hcc hdac9 hepatocellular implanted integrin intrahepatic intriguingly lost metastasis mir monocytic moz myst orthotopic orthotopically smmc sulfatide sulfotransferase verified	abnormality accumbens ach3 adhd behavioural caudate deficit disrupted disruption dorsal exploratory habituation ht hydroxytryptamine hyperactivity mesocorticolimbic mesolimbic modulatory monoamine monoaminergic permanent putamen raphe serotonin tralpha tralpha0 trbeta trs
Tagcloud (Intersection) ?