HDAC10 and PAX3

Number of citations of the paper that reports this interaction (PubMedID 20032463)
37

Data Source:
BioGRID (pull down, pull down)

		HDAC10	PAX3
Description		histone deacetylase 10	paired box 3
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Histone Deacetylase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Deacetylase Activity Enzyme Binding Protein Lysine Deacetylase Activity Histone Deacetylase Binding Metal Ion Binding Acetylputrescine Deacetylase Activity Acetylspermidine Deacetylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Recombination Chromatin Organization Regulation Of DNA-templated Transcription Autophagy DNA Damage Response Macroautophagy Positive Regulation Of Mismatch Repair Homologous Recombination Negative Regulation Of DNA-templated Transcription Macromolecule Deacylation Polyamine Deacetylation Spermidine Deacetylation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Muscle Organ Development Sensory Perception Of Sound Anatomical Structure Morphogenesis Animal Organ Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway	HATs acetylate histones Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac
Diseases			Alveolar rhabdomyosarcoma Waardenburg syndrome (WS) Craniofacial-deafness-hand syndrome
GWAS		Acne (severe) ( 24927181) Urinary metabolite levels in chronic kidney disease ( 31959995)	Adolescent idiopathic scoliosis ( 26394188) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132) Facial morphology ( 22341974 31763980) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Information processing speed ( 25869804) Male-pattern baldness ( 28196072) middle facial morphology traits (quantitative measurement) ( 27193062) Monobrow ( 27182965) Monobrow thickness ( 26926045) Nose size ( 27182965) Vitamin D levels ( 25208829) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		9 interacting genes: HDAC2 HDAC3 HSPA8 MDC1 MTNR1A NCOR2 PAX3 TRIM28 TRIM54	18 interacting genes: CIB1 DAXX FZR1 HDAC10 IPO13 KRTAP6-2 KRTAP8-1 MEOX1 MEOX2 MITF MSX1 POU3F2 RAD23B SOX10 SOX8 TAF1 TBP WWTR1
Entrez ID		83933	5077
HPRD ID		09407	09421
Ensembl ID		ENSG00000100429	ENSG00000135903
Uniprot IDs		Q969S8	P23760
PDB IDs			3CMY
Enriched GO Terms of Interacting Partners?		Protein De-2-hydroxyisobutyrylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Rhythmic Process Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Histone Deacetylase Binding Heterochromatin Formation Circadian Rhythm Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin NF-kappaB Binding Transcription Corepressor Activity Positive Regulation Of Protein Import Into Nucleus Histone Deacetylase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Circadian Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Male Mating Behavior Heat Shock Protein Binding Response To Lipid Chaperone-mediated Autophagy Translocation Complex Disassembly Transcription Repressor Complex Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Ferroptosis Cellular Response To Stress Chromatin Organization Promoter-specific Chromatin Binding Nucleoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Enzyme Binding Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Transcription By RNA Polymerase II Lumenal Side Of Lysosomal Membrane Krueppel-associated Box Domain Binding Positive Regulation Of Protein Localization To Nucleus Regulation Of Protein Transport Regulation Of Interleukin-1 Production Fungiform Papilla Formation Regulation Of Protein Import Ubiquitin-like Protein Ligase Activity	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Regulator Complex Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Somite Specification Positive Regulation Of Biosynthetic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity P53 Binding Positive Regulation Of DNA-templated Transcription Initiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Enteric Nervous System Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Nucleoplasm Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Segment Specification Somite Development Regulation Of Cell Population Proliferation Transcription Cis-regulatory Region Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Melanocyte Differentiation
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