SMURF2 and RAB13

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		SMURF2	RAB13
Gene Name		SMAD specific E3 ubiquitin protein ligase 2	RAB13, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft	Cytoplasm Golgi Apparatus Trans-Golgi Network Plasma Membrane Tight Junction Lateral Plasma Membrane Lamellipodium Endocytic Vesicle Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Insulin-responsive Compartment Neuron Projection Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Ligase Activity Identical Protein Binding SMAD Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway	Intracellular Protein Transport Protein Kinase A Signaling Endosomal Transport Cortical Actin Cytoskeleton Organization Neuron Projection Development Endocytic Recycling Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Endothelial Cell Chemotaxis Trans-Golgi Network To Recycling Endosome Transport Membrane Organization Tight Junction Assembly Establishment Of Protein Localization To Plasma Membrane Establishment Of Sertoli Cell Barrier Protein Localization To Cell Leading Edge
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Asymmetric localization of PCP proteins Signaling by Hedgehog degradation of AXIN Signaling by WNT in cancer PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		79 interactors: ACBD3 ACOX3 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FAM175B FKBP4 FLNB GNG2 HDGFRP3 ING2 IRF3 IRF8 KLF5 LAPTM5 LATS1 MAVS NEK6 NKIRAS1 NRAS PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNRNP70 SOCS6 SPG20 SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D3 UBE2L3 YY1 ZBTB44	5 interactors: PDE6D RABGAP1L SMAD4 SMURF2 TGFBR1
Entrez ID		64750	5872
HPRD ID		06901	04053
Ensembl ID			ENSG00000143545
Uniprot IDs		Q96DE7 Q9HAU4	P51153 Q504R6
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Signal Transduction Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Signaling Protein Polyubiquitination Response To Stimulus Epithelium Development Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Regulation Of Protein Metabolic Process Multicellular Organismal Development Tissue Development Protein Modification By Small Protein Conjugation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Organ Development Regulation Of RNA Metabolic Process Anatomical Structure Development	Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of SMAD Protein Import Into Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of SMAD Protein Import Into Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neuron Fate Commitment BMP Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Import Into Nucleus Response To Growth Factor Palate Development Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Mesenchymal Cell Development Mesenchymal Cell Differentiation Regulation Of Protein Localization Nephrogenic Mesenchyme Morphogenesis Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Enzyme Linked Receptor Protein Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Regulation Of Protein Localization To Nucleus Mesenchyme Development Regulation Of Nucleocytoplasmic Transport Heart Morphogenesis Regulation Of Signal Transduction DNA-templated Transcription, Initiation Positive Regulation Of Intracellular Transport Stem Cell Development Anterior/posterior Pattern Specification Regulation Of Binding Regulation Of Intracellular Protein Transport Endocardial Cell Differentiation Regulation Of Signaling Ubiquitin-dependent SMAD Protein Catabolic Process
Tagcloud ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	analyzing breakpoint cdk2 census chips database degs disks dlg4 downloaded encyclopedia featured fgfr fgfr2 gbm gse4290 homologue kegg kyoto multiforme nbpf10 neuroblastoma nras omnibus pairs pathogenetic perturbing reversal
Tagcloud (Difference) ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	analyzing breakpoint cdk2 census chips database degs disks dlg4 downloaded encyclopedia featured fgfr fgfr2 gbm gse4290 homologue kegg kyoto multiforme nbpf10 neuroblastoma nras omnibus pairs pathogenetic perturbing reversal
Tagcloud (Intersection) ?