SMURF2 and KLF5

Number of citations of the paper that reports this interaction (PMID 21953463)
6

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SMURF2	KLF5
Gene Name		SMAD specific E3 ubiquitin protein ligase 2	Kruppel-like factor 5 (intestinal)
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft	Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Ligase Activity Identical Protein Binding SMAD Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Microvillus Assembly Regulation Of Microvillus Assembly Skeletal Muscle Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intestinal Epithelial Cell Development Cellular Response To Organic Cyclic Compound Cellular Response To Peptide
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Asymmetric localization of PCP proteins Signaling by Hedgehog degradation of AXIN Signaling by WNT in cancer PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS			Pancreatic cancer ( 20101243)
Protein-Protein Interactions		79 interactors: ACBD3 ACOX3 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FAM175B FKBP4 FLNB GNG2 HDGFRP3 ING2 IRF3 IRF8 KLF5 LAPTM5 LATS1 MAVS NEK6 NKIRAS1 NRAS PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNRNP70 SOCS6 SPG20 SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D3 UBE2L3 YY1 ZBTB44	18 interactors: CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HDAC1 NFKB1 PRKCA PRKCD RARA SET SMURF2 TBP WWP1
Entrez ID		64750	688
HPRD ID		06901	04212
Ensembl ID			ENSG00000102554
Uniprot IDs		Q96DE7 Q9HAU4	A2TJX0 Q13887 Q5T6X2
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ	2EBT
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Signal Transduction Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Signaling Protein Polyubiquitination Response To Stimulus Epithelium Development Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Regulation Of Protein Metabolic Process Multicellular Organismal Development Tissue Development Protein Modification By Small Protein Conjugation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Organ Development Regulation Of RNA Metabolic Process Anatomical Structure Development	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Nitrogen Compound Metabolic Process Viral Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process
Tagcloud ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	3t3 activities adipocyte adipocytes adipogenesis adipogenic ampk ap2 atorvastatin attractive cascades combination diseases ebpalpha elevated excessive exerts homeostasis l1 master metformin obesity ppargamma regulator regulators smad7 stat3 suppressed tgf
Tagcloud (Difference) ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate resonance state structural terminal transthiolation ub ubiquitin	3t3 activities adipocyte adipocytes adipogenesis adipogenic ampk ap2 atorvastatin attractive cascades combination diseases ebpalpha elevated excessive exerts homeostasis l1 master metformin obesity ppargamma regulator smad7 stat3 suppressed tgf
Tagcloud (Intersection) ?		regulators