SMURF2 and SPG20

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMURF2	SPG20
Gene Name		SMAD specific E3 ubiquitin protein ligase 2	spastic paraplegia 20 (Troyer syndrome)
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft	Cytoplasm Mitochondrial Outer Membrane Lipid Particle Plasma Membrane Midbody Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Ligase Activity Identical Protein Binding SMAD Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Particle Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Asymmetric localization of PCP proteins Signaling by Hedgehog degradation of AXIN Signaling by WNT in cancer PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		79 interactors: ACBD3 ACOX3 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FAM175B FKBP4 FLNB GNG2 HDGFRP3 ING2 IRF3 IRF8 KLF5 LAPTM5 LATS1 MAVS NEK6 NKIRAS1 NRAS PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNRNP70 SOCS6 SPG20 SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D3 UBE2L3 YY1 ZBTB44	9 interactors: APP EPS15 ITCH PLIN3 SMURF1 SMURF2 TUBA1A WWP2 ZFYVE9
Entrez ID		64750	23111
HPRD ID		06901	06170
Ensembl ID			ENSG00000133104
Uniprot IDs		Q96DE7 Q9HAU4	Q8N0X7
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ	2DL1
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Signal Transduction Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Signaling Protein Polyubiquitination Response To Stimulus Epithelium Development Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Regulation Of Protein Metabolic Process Multicellular Organismal Development Tissue Development Protein Modification By Small Protein Conjugation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Organ Development Regulation Of RNA Metabolic Process Anatomical Structure Development	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Negative Regulation Of Signaling Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Protein Ubiquitination Response To Transforming Growth Factor Beta Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K63-linked Ubiquitination Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Viral Entry Into Host Cell Intracellular Transport Proteolysis Entry Into Host Cell Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Complex Assembly Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway BMP Signaling Pathway Establishment Of Localization In Cell Regulation Of ERBB Signaling Pathway Interaction With Host Synaptic Growth At Neuromuscular Junction Protein Metabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Localization Cellular Response To Growth Factor Stimulus Collateral Sprouting In Absence Of Injury Response To Growth Factor Notch Signaling Pathway Cytoskeleton-dependent Intracellular Transport Vesicle-mediated Transport Cellular Macromolecular Complex Assembly Endocytosis
Tagcloud ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	adenocarcinoma arid1a cdkn2a contributor contributors dinucleotides dock2 eac elmo1 esophageal exome greatly identifies modifying mutated mutational pairs pik3ca rac1 risen sequencing signature smad4 spectra subjected tlr4 transversions tumorigenesis whole
Tagcloud (Difference) ?		autoinhibitory biochemical c2 catalytic controlled domain dysregulation e3 e3s framework hect impaired interaction intramolecular ligases magnetic maintaining nedd4 nmr noncovalent regulate regulators resonance state structural terminal transthiolation ub ubiquitin	adenocarcinoma arid1a cdkn2a contributor contributors dinucleotides dock2 eac elmo1 esophageal exome greatly identifies modifying mutated mutational pairs pik3ca rac1 risen sequencing signature smad4 spectra subjected tlr4 transversions tumorigenesis whole
Tagcloud (Intersection) ?